Modulation of Visual-Spatial Learning in Healthy Older Adults by tDCS

NCT ID: NCT02110056

Last Updated: 2018-01-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

32 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-03-31

Study Completion Date

2015-11-30

Brief Summary

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The aim of this study is to investigate whether a combination of intensive training of visual-spatial abilities (LOCATO task) with anodal transcranial direct current stimulation (tDCS) leads to an improvement of learning and memory in healthy older adults and to examine the underlying neuronal mechanism.

Detailed Description

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Conditions

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Healthy Older Adults

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Caregivers

Study Groups

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training + tDCS

Combination of intensive training of visual-spatial abilities (LOCATO task) with transcranial direct current stimulation (tDCS)

Group Type EXPERIMENTAL

tDCS

Intervention Type DEVICE

transcranial direct current stimulation (tDCS)

training

Intervention Type BEHAVIORAL

intensive training of visual-spatial abilities (in LOCATO task)

training + sham stimulation

Combination of intensive training of visual-spatial abilities (LOCATO task) with sham stimulation

Group Type SHAM_COMPARATOR

tDCS

Intervention Type DEVICE

transcranial direct current stimulation (tDCS)

training

Intervention Type BEHAVIORAL

intensive training of visual-spatial abilities (in LOCATO task)

Interventions

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tDCS

transcranial direct current stimulation (tDCS)

Intervention Type DEVICE

training

intensive training of visual-spatial abilities (in LOCATO task)

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* right handedness
* unobtrusive neuropsychological screening
* age: 50-90 years

Exclusion Criteria

* severe internal or psychiatric disease
* epilepsy
* other severe neurological diseases, e.g. previous major stroke or brain tumor
* DMS-IV manifest dementia
* contraindication for MRT (claustrophobia, metallic implants, tattoos)
Minimum Eligible Age

50 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Charite University, Berlin, Germany

OTHER

Sponsor Role lead

Responsible Party

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Agnes Flöel

Prof. Dr.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Agnes Flöel, Prof. Dr.

Role: PRINCIPAL_INVESTIGATOR

Charite University, Berlin, Germany

Locations

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Charite Universitätsmedizin Berlin

Berlin, , Germany

Site Status

Countries

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Germany

References

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Antonenko D, Kulzow N, Cesarz ME, Schindler K, Grittner U, Floel A. Hippocampal Pathway Plasticity Is Associated with the Ability to Form Novel Memories in Older Adults. Front Aging Neurosci. 2016 Mar 22;8:61. doi: 10.3389/fnagi.2016.00061. eCollection 2016.

Reference Type RESULT
PMID: 27047376 (View on PubMed)

Antonenko D, Kulzow N, Sousa A, Prehn K, Grittner U, Floel A. Neuronal and behavioral effects of multi-day brain stimulation and memory training. Neurobiol Aging. 2018 Jan;61:245-254. doi: 10.1016/j.neurobiolaging.2017.09.017. Epub 2017 Sep 28.

Reference Type RESULT
PMID: 29050849 (View on PubMed)

Other Identifiers

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LOCATO-OA-tDCS

Identifier Type: -

Identifier Source: org_study_id

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