Investigating HD-tDCS in Improving Word Finding and Memory Retrieval in Individuals With MCI

NCT ID: NCT03446508

Last Updated: 2022-02-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2017-11-18

Study Completion Date

2022-01-25

Brief Summary

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This study is attempting to improve word finding and memory retrieval problems persons with mild cognitive impairment (MCI) may have.

Detailed Description

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This study attempts to improve word finding and memory retrieval problems in persons with mild cognitive impairment (MCI). To remember and find words, the brain has to search for the correct memory and MCI can negatively affect this search. Studies have suggested that low level electrical stimulation of the memory retrieval circuit can improve memory recall. The purpose of this study is to find the exact influence of multi-electrode or High Definition transcranial Direct Current Stimulation (HD-tDCS) by targeting a frontal and a parietal brain area, and their roles in memory retrieval/word finding in MCI. By modulating ongoing activity in 6 sessions of HD-tDCS the study investigates whether HD-tDCS may be used as a way to improve memory retrieval/word finding evaluated by cognitive measures and electroencephalography (EEG) measures before the first session and after the last session of HD-tDCS with a follow-up session 1-month after the stimulation procedure.

Conditions

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Mild Cognitive Impairment

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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Active frontal

Active HD-tDCS

Group Type EXPERIMENTAL

Active frontal

Intervention Type DEVICE

1\) active HD-tDCS will be administered

Active parietal

Active HD-tDCS

Group Type EXPERIMENTAL

Active parietal

Intervention Type DEVICE

2\) active HD-tDCS will be administered

Sham control

Sham HD-tDCS

Group Type SHAM_COMPARATOR

Sham

Intervention Type DEVICE

3\) sham HD-tDCS - no current

Interventions

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Active frontal

1\) active HD-tDCS will be administered

Intervention Type DEVICE

Active parietal

2\) active HD-tDCS will be administered

Intervention Type DEVICE

Sham

3\) sham HD-tDCS - no current

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Age between 40 and 90
2. Capable of understanding and signing an informed consent
3. Experiencing severe memory problems

Exclusion Criteria

1. Severe organic co-morbidity
2. Pace maker / defibrillator
3. Pregnancy
Minimum Eligible Age

40 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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The University of Texas at Dallas

OTHER

Sponsor Role lead

Responsible Party

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Sven Vanneste

Associate professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sven Vanneste, PhD

Role: PRINCIPAL_INVESTIGATOR

The University of Texas at Dallas

Locations

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University of Texas at Dallas

Richardson, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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18-21

Identifier Type: -

Identifier Source: org_study_id

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