Noninvasive Brain Stimulation on Memory in Individuals With Mild Cognitive Impairment and History of Brain Injury
NCT ID: NCT04504630
Last Updated: 2026-01-13
Study Results
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View full resultsBasic Information
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COMPLETED
NA
26 participants
INTERVENTIONAL
2020-12-05
2025-01-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Active HD-tDCS
Participants will receive 10 sessions of active stimulation (1 mA anodal HD-tDCS targeting dorsal anterior cingulate region for 20 minutes) across 2 weeks, with episodic memory tasks completed at baseline, immediate follow-up after session 10, and a 3-month follow-up.
High Definition Transcranial Direct Current Stimulation
This wireless device delivers a very low electrical current to focused regions on the scalp in order to modulate underlying brain circuits to promote neuroplasticity. The device will be fitted onto a neoprene EEG cap, with 1 anode electrode placed and surrounded by 4 cathode electrodes in a ring pattern. Electrical stimulation will be applied using a constant voltage cortical stimulator (Model D185, Digitimer Ltd, UK, maximal output 1000 V/1.5 A) with single square-wave 50-μs pulses (0.1 A/μs rise time).
Sham HD-tDCS
Participants will receive 10 sessions of sham stimulation across 2 weeks, with episodic memory tasks completed at baseline, immediate follow-up after session 10, and a 3-month follow-up.
Sham HD-tDCS
Sham HD-tDCS
Interventions
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High Definition Transcranial Direct Current Stimulation
This wireless device delivers a very low electrical current to focused regions on the scalp in order to modulate underlying brain circuits to promote neuroplasticity. The device will be fitted onto a neoprene EEG cap, with 1 anode electrode placed and surrounded by 4 cathode electrodes in a ring pattern. Electrical stimulation will be applied using a constant voltage cortical stimulator (Model D185, Digitimer Ltd, UK, maximal output 1000 V/1.5 A) with single square-wave 50-μs pulses (0.1 A/μs rise time).
Sham HD-tDCS
Sham HD-tDCS
Eligibility Criteria
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Inclusion Criteria
* Native English speakers
* 12 years of education or higher
* Active diagnosis of aMCI
* History of TBI based on VA/DOD criteria
Exclusion Criteria
* Lifetime history of stroke, transient ischemic attack, heart attack, or congestive heart failure
* Lifetime history of epilepsy
* Major psychiatric disorders (i.e., posttraumatic stress disorder, bipolar disorder, schizophrenia)
* Substance use disorder
* Has metal fragments in head
* Taking medications that may interact with the HD-tDCS effect (i.e., amphetamines, L-dopa, carbamazepine, sulpiride, pergolide, lorazepam, dextromethorphan, D-cycloserine, flunarizine, or ropinirole)
50 Years
ALL
No
Sponsors
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Congressionally Directed Medical Research Programs
FED
University of Texas Southwestern Medical Center
OTHER
Responsible Party
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Christian Lobue
Associate Professor
Locations
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University of Texas Southwestern Medical Center
Dallas, Texas, United States
Countries
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Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Document Type: Informed Consent Form
Other Identifiers
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CDMRP-AZ190088
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
STU-2019-1769
Identifier Type: -
Identifier Source: org_study_id
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