Mitochondria and Muscle Health in Elderly

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

COMPLETED

Total Enrollment

59 participants

Study Classification

OBSERVATIONAL

Study Start Date

2017-06-27

Study Completion Date

2021-04-09

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

The aim of this study is to characterize the relation between skeletal muscle mitochondrial metabolism and muscle health in elderly, physically compromised humans. To study this relation, a cross-sectional study will be performed in well-defined, distinct subject groups. Thus, to obtain insight in the relation between mitochondrial health and muscle function, not only subjects that differ in mitochondrial function (based on physical activity) will be compared but also subjects with high- versus low muscle function will be selected.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

The Effects of Resistance Training and Protein Supplementation in Healthy Elderly Men and Women.

NCT01004588

Muscle Loss in Elderly

COMPLETED NA

A Protein Supplementation and Exercise Strategy to Promote Muscle Protein Anabolism in Frail Elderly People

NCT01110369

Sarcopenia

COMPLETED NA

Combined Nutrient Intake and Muscle Protein Synthesis

NCT01239277

Aging

COMPLETED NA

Protein Supplementation to Promote Muscle Protein Anabolism in Frail Elderly People

NCT01109628

Sarcopenia

COMPLETED NA

Protein Supply in Elderly

NCT01317511

Muscle Synthesis

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Aging is associated with a decline of mitochondrial and skeletal muscle volume, -quality and -function. If a causal link exists between the loss of mitochondrial function and muscle health is unknown, however, both appear with advancing age and are associated with the loss of functional capacity, which increases comorbidities and annual healthcare costs. The aim is to test the hypothesis that a compromised muscle function in sedentary elderly is related to an impaired mitochondrial health. A detailed characterization of mitochondrial metabolism and muscle function is performed in well-defined, (physically compromised) elderly humans, in a cross-sectional design. To obtain insight in the relation between mitochondrial health and muscle function, not only elderly subjects that differ in mitochondrial function (based on physical activity) will be compared but also elderly subjects with high versus low muscle physical function will be selected. Healthy, young (20-30 years,) individuals with normal physical activity levels will be included as absolute controls.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Muscle Weakness

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Young healthy subjects

20-30 years old, max 1h of exercise per week

No interventions assigned to this group

Elderly with a normal physical function

65-80 years old, max 1h of exercise per week

No interventions assigned to this group

Elderly with a decreased physical function

65-80 years old, max 1h of exercise per week, SPPB under 9 or frailty score lower then 10

No interventions assigned to this group

Active elderly

65-80 years old, minimal 3h of exercise per week

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Males and females
* Subject should be in sufficient health to participate in the experimentations, to be judged by the responsible MD based on the subject's medical history
* Caucasian origin (see study groups)

Exclusion Criteria

* Any contraindications for MRI scan:

Aneurysm clips Implanted neural stimulator Implanted cardiac pacemaker of defibrillator Cochlear implant Iron- containing corpora aliena in the eye or brain Artificial (heart) valves which is contraindicated for MRS Claustrophobia

* Diagnosed with diabetes mellitus
* Poor health as judged by the responsible medical doctor
* Heart problems: In case of an abnormal ECG in rest, this will be discussed with both the participant and the responsible medical doctor

Minimum Eligible Age

65 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes