The Effect of PACAP27 on the Extra- and Intracerebral Arteries Assessed by Magnetic Resonance Angiography (MRA) on Healthy Volunteers
NCT ID: NCT03560024
Last Updated: 2019-02-12
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
18 participants
INTERVENTIONAL
2018-05-31
2018-12-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
OTHER
DOUBLE
Study Groups
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PACAP27
12 healthy volunteers will receive PACAP27 (10 picomole/kg/min) over 20 min
PACAP27
PACAP27 is vasodilator of cerebral vessels
Placebo
6 healthy volunteers will receive placebo (Saline) over 20 min
Placebo
Saline
Interventions
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PACAP27
PACAP27 is vasodilator of cerebral vessels
Placebo
Saline
Eligibility Criteria
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Inclusion Criteria
* Aged 18-50
* 50-100 kg
Exclusion Criteria
* Other primary headaches
* Daily medication except contraceptives
* Drug taken within 4 times the half-life for the specific drug except contraceptives
* Pregnant or lactating women
* Exposure to radiation within the last year
* Headache within the last 24 hours before start of trial
* Hypertension
* Hypotension
* Respiratory or cardiac disease
* Primary relatives with current or previous migraine
18 Years
50 Years
ALL
Yes
Sponsors
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Danish Headache Center
OTHER
Responsible Party
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Hashmat Ghanizada
Principal Investigator
Locations
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Danish Headache Center
Glostrup Municipality, , Denmark
Countries
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Other Identifiers
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H-18016693
Identifier Type: -
Identifier Source: org_study_id
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