Natriuretic Peptide's Headache Inducing Characteristics and Effects on the Cerebral Blood Flow

NCT ID: NCT01637662

Last Updated: 2015-07-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

6 participants

Study Classification

INTERVENTIONAL

Study Start Date

2012-07-31

Brief Summary

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To investigate headache score and accompanying symptoms during and after infusion of the natriuretic peptides.

Detailed Description

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Conditions

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Headache Migraine

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

CROSSOVER

Primary Study Purpose

SCREENING

Blinding Strategy

NONE

Study Groups

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Healthy subjects

Group Type EXPERIMENTAL

Natriuretic peptides

Intervention Type DRUG

I.V. infusion between 0.2-3 microgram over 20 minutes

Interventions

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Natriuretic peptides

I.V. infusion between 0.2-3 microgram over 20 minutes

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy volunteers
* Aged 18-40
* 50-100 kg
* Fertile women must use safe contraceptives (IUD, oral contraceptives, surgical sterilisation and long lasting gestagen.

Exclusion Criteria

* Tension type headache more than once/month
* Other primary headaches
* Daily medication except contraceptives
* Drug taken within 4 times the halflife for the specific drug except contraceptives
* Pregnant or lactating women
* Exposure to radiation within the last year
* Headache within the last 24 hours before start of trial
* Hypertension
* Hypotension
* Respiratory or cardiac disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Danish Headache Center

OTHER

Sponsor Role lead

Responsible Party

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Song Guo

MD

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Danish Headache Center

Copenhagen, Glostrup, Denmark

Site Status

Countries

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Denmark

Other Identifiers

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H-3-2012-065

Identifier Type: -

Identifier Source: org_study_id

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