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PGI2 Induced Headache and Cerebral Haemodynamics in Healthy Volunteers

NCT ID: NCT00291395

Last Updated: 2006-10-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Clinical Phase

PHASE1

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2005-09-30

Brief Summary

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Before , during and after intravenous administration of PGI2 we score/measure headache, rCBF, blood flow in middle cerebral artery and diameter of superficial temporal artery/radial artery and correlate that to known patophysiology of headache to see if PGI2 is involved in headache pathophysiology.

Detailed Description

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Conditions

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Headache Migraine

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

CROSSOVER

Blinding Strategy

DOUBLE

Interventions

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PGI2

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy volunteers,

Exclusion Criteria

* Primary headache,
* headache on the day of investigation,
* Hypertension,
* hypotension,
* pregnant/nursing
* Daily intake of medication (except oral contraceptives)
* Cardiovascular or CNS disease
* Drug/Alcohol abuse
* Psychiatric disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

40 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Danish Headache Center

OTHER

Sponsor Role lead

Principal Investigators

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Troels Wienecke, MD

Role: PRINCIPAL_INVESTIGATOR

Danish Headache Center

Locations

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Danish Headache Center

Glostrup Municipality, Glostrup, Denmark

Site Status

Countries

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Denmark

Other Identifiers

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KA05055

Identifier Type: -

Identifier Source: org_study_id