Carbon Monoxide Migraine-inducing Effects in Patients With Migraine Without Aura.
NCT ID: NCT03075020
Last Updated: 2017-12-21
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
12 participants
INTERVENTIONAL
2016-10-31
2017-12-20
Brief Summary
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Detailed Description
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With transcranial Doppler imaging, c-scan and laser speckle the investigators will investigate changes in blood flow velocity of the middle cerebral artery (MCA), diameter of the superficial temporal artery (STA), the radial artery and facial skin perfusion.
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
BASIC_SCIENCE
DOUBLE
Study Groups
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Active carbon monoxide
Inhalation of carbon monoxide up to a carboxyhemoglobin concentration 22%
Carbon monoxide
carbon monoxide, 4.7, Purity 99.997, inhalation of carbon monoxide in a volume corresponding to carboxyhemoglobin 10 and 20%, calculated from baseline Hg and body mass
Air
AIR
Room air will be administered as placebo
Interventions
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Carbon monoxide
carbon monoxide, 4.7, Purity 99.997, inhalation of carbon monoxide in a volume corresponding to carboxyhemoglobin 10 and 20%, calculated from baseline Hg and body mass
AIR
Room air will be administered as placebo
Eligibility Criteria
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Inclusion Criteria
* Aged 18-50
* 50-100 kg
Exclusion Criteria
* Other primary headaches
* Daily medication except contraceptives
* Drug taken within 4 times the halflife for the specific drug except contraceptives
* Pregnant or lactating women
* Exposure to radiation within the last year
* Headache within the last 24 hours before start of trial
* Hypertension
* Hypotension
* Respiratory or cardiac disease
* Smoking
* Primary relatives with current or previous migraine
18 Years
50 Years
ALL
Yes
Sponsors
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Danish Headache Center
OTHER
Responsible Party
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Hashmat Ghanizada
MD
Locations
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Danish Headache Center
Glostrup Municipality, , Denmark
Countries
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Other Identifiers
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H-16021497
Identifier Type: -
Identifier Source: org_study_id