The Hemodynamic Effects of PACAP38 After Glibenclamide Administration in Healthy Volunteers
NCT ID: NCT04960657
Last Updated: 2021-07-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
22 participants
INTERVENTIONAL
2020-10-20
2021-03-19
Brief Summary
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Detailed Description
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The aim of the study is to investigate the vascular effect of PACAP38 after glibenclamide administration.
Repeated measurements covering the arteria radialis (RA), superficial temporal artery (STA) and middle cerebral artery (MCA) before and after PACAP38 infusion and glibenclamide/placebo administration
Conditions
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Study Design
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RANDOMIZED
CROSSOVER
OTHER
QUADRUPLE
Study Groups
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PACAP38 and glibenclamide
Participants will receive glibenclamide after PACAP38 infusion
glibenclamide
Oral administration of glibenclamide/placebo. To investigate the role of PACAP38 on cranial arteries in healthy volunteers after glibenclamide/placebo administration .
PACAP38
PACAP38 infusion
PACAP38 and placebo
Participants will receive placebo after PACAP38 infusion
glibenclamide
Oral administration of glibenclamide/placebo. To investigate the role of PACAP38 on cranial arteries in healthy volunteers after glibenclamide/placebo administration .
PACAP38
PACAP38 infusion
Interventions
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glibenclamide
Oral administration of glibenclamide/placebo. To investigate the role of PACAP38 on cranial arteries in healthy volunteers after glibenclamide/placebo administration .
PACAP38
PACAP38 infusion
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* 18-60 years.
* 50-100 kg.
* Women of childbearing age must use adequate contraception
Exclusion Criteria
* Migraine or any other type of headache (except episodic tension-type headache less than 5 days per month)
* Daily intake of any medication except contraceptives
18 Years
60 Years
ALL
Yes
Sponsors
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Danish Headache Center
OTHER
Responsible Party
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Lili Kokoti
MD, PhD student, Principal investigator
Locations
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Danish Headache Center
Copenhagen, Capital Region, Denmark
Countries
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Other Identifiers
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H19065735
Identifier Type: -
Identifier Source: org_study_id
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