The Role of Inflammation and Vasodilatation in PACAP38-induced Headache Using MRI on Healthy Subjects
NCT ID: NCT03585894
Last Updated: 2020-01-02
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
34 participants
INTERVENTIONAL
2018-08-01
2019-11-25
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
OTHER
TRIPLE
Study Groups
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Sumatriptan
Sumatriptan 4 mg/mL I.V will be administrated over 10 min
Sumatriptan
Receive intravenous infusion of sumatriptan
Ketorolac
Ketorolac 30 mg/mL I.V will be administrated over 10 min
Ketorolac
Receive intravenous infusion of ketorolac
Interventions
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Sumatriptan
Receive intravenous infusion of sumatriptan
Ketorolac
Receive intravenous infusion of ketorolac
Eligibility Criteria
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Inclusion Criteria
* Aged 18-50
* 50-100 kg
Exclusion Criteria
* Other primary headaches
* Daily medication except contraceptives
* Drug taken within 4 times the half-life for the specific drug except contraceptives
* Pregnant or lactating women
* Exposure to radiation within the last year
* Headache within the last 24 hours before start of trial
* Hypertension
* Hypotension
* Respiratory or cardiac disease
* Primary relatives with current or previous migraine
18 Years
50 Years
ALL
Yes
Sponsors
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Danish Headache Center
OTHER
Responsible Party
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Hashmat Ghanizada
Principal investigator
Locations
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Danish Headache Center
Glostrup Municipality, , Denmark
Countries
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References
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Ghanizada H, Al-Karagholi MA, Arngrim N, Morch-Rasmussen M, Metcalf-Clausen M, Larsson HBW, Amin FM, Ashina M. Investigation of sumatriptan and ketorolac trometamol in the human experimental model of headache. J Headache Pain. 2020 Feb 24;21(1):19. doi: 10.1186/s10194-020-01089-3.
Other Identifiers
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H-18008313
Identifier Type: -
Identifier Source: org_study_id
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