Nutrition for Migraine Prevention

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

182 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-07-31

Study Completion Date

2018-05-11

Brief Summary

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Migraine is a widespread, debilitating, chronic pain disorder and a major public health challenge. Most conventional, pharmaceutical treatments fail to give satisfactory long-term relief and their repeated use can have important side effects. This project involves implementation of substantial dietary changes in adults with migraine. Our goal is to test the hypothesis that a causal relationship exists between migraine symptoms and the amount and proportions of foods consumed containing defined amounts of polyunsaturated fatty acids.

Significant findings supporting the hypothesis will lead to a major shift in both prevention and management of migraine and other chronic pain disorders. Emphasis is on low-cost, health improvement strategies utilizing specific dietary modifications for pain management, based on solid clinical research evidence.

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Detailed Description

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Episodic migraine is a debilitating chronic pain condition afflicting 12% of American adults. Current conventional treatments rely on medications that provide limited or transient relief, target symptoms rather than the underlying causes of pain, and are associated with significant side effects and costs. It is therefore essential to investigate non-pharmacologic approaches to conventional headache treatments. Certain fatty acids and their bioactive metabolites regulate multiple pain-related biochemical pathways. Controlled clinical trials investigating pain modulation in response to dietary changes while exploring relevant mechanisms of action in humans are lacking.

In a recent feasibility study in patients with chronic daily headache (CDH), we found that targeted fatty acid modifications altered circulating endovanilloids, while reducing headache frequency and improving quality of life. These findings support our proposed model in which diet-induced alterations in endovanilloids modulate transient receptor potential cation channel subfamily V member 1 (TRPV1) activity in vivo, leading to important implications for migraine and chronic pain in general.

The goal of this research is to assess whether dietary PUFA modifications can result in predicted changes in circulating endovanilloids and improvement in headache-related clinical outcomes. The proposed 3-arm, 26-week,randomized, controlled, single-blind trial, with 51 subjects in each group, includes a 4-week baseline of usual care, followed by randomization to one of three 22-week dietary interventions plus usual care. Each of the three arms involves specific modifications of dietary fatty acid intakes through a whole foods diet. Participants in the dietary interventions receive food sufficient for 2 meals and 2 snacks daily along with extensive dietary counseling.

Specific aims are:

1. To assess the efficacy of the dietary interventions in inducing the predicted changes in circulating fatty acid endovanilloid derivatives;
2. To compare the clinical effects in migraine specific outcomes of two 16-week analgesic dietary interventions with each other and a control diet;
3. To test, in an exploratory manner, our model of the proposed causal chain linking changes in fatty acids, their endovanilloid derivatives, and headache clinical endpoints.

This proposal utilizes an innovative design and hypotheses to address current research funding priorities, by examining clinical efficacy and underlying mechanisms of a promising dietary manipulation with the distinct potential for high impact in terms of ameliorating a chronic, disabling pain disorder.

Conditions

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Migraine Disorders

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

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Diet A

Whole food diet modifies dietary fatty acids. Foods provided for 16 weeks; study oils provided for 22 weeks.

Group Type EXPERIMENTAL

Diet

Intervention Type OTHER

The dietary intervention provides dietary counseling, whole foods (enough for 2 meals and 2 snacks per day) including study oils

Diet B

Whole food diet modifies dietary fatty acids. Foods provided for 16 weeks; study oils provided for 22 weeks.

Group Type EXPERIMENTAL

Diet

Intervention Type OTHER

The dietary intervention provides dietary counseling, whole foods (enough for 2 meals and 2 snacks per day) including study oils

Diet C

Whole food diet modifies dietary fatty acids. Foods provided for 16 weeks; study oils provided for 22 weeks.

Group Type ACTIVE_COMPARATOR

Diet

Intervention Type OTHER

The dietary intervention provides dietary counseling, whole foods (enough for 2 meals and 2 snacks per day) including study oils

Interventions

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Diet

The dietary intervention provides dietary counseling, whole foods (enough for 2 meals and 2 snacks per day) including study oils

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* 18 years of age or older
* Either gender
* Meets 2004 International Classification of Headache Disorders-II\* criteria for Episodic Migraine
* Frequent migraine headaches
* Headache history: \> 2 years leading up to study meeting migraine criteria
* Willing to complete daily diary for 26 weeks
* Able to attend 8 dietitian counseling sessions
* Under care of a physician for headaches
* Able to read and communicate in English

Exclusion Criteria

* Marked depression, anxiety or psychosis.
* History of specific food allergies, such as, but not limited to, dairy or gluten products
* Pregnancy or anticipated pregnancy
* Active treatment for a major medical illness, such as malignancy, autoimmune, immune deficiency disorder, etc.
* History of significant head trauma or head/neck surgery within the past 3 years
* History of subarachnoid or intra-cerebral hemorrhage or subdural hematoma
* Allergy to fish or strong aversion to fish consumption.
* History of nervous system infection such as meningitis or encephalitis within the preceding 5 years
* History of vasculitis, intracranial mass, clotting disorder
* Cognitive dysfunction that would prevent informed consent

Minimum Eligible Age

18 Years

Maximum Eligible Age

99 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No