An Assessment of Cognitive Improvement Training Among Mid-life Individuals
NCT ID: NCT03501706
Last Updated: 2024-05-10
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
680 participants
INTERVENTIONAL
2014-11-01
2024-07-31
Brief Summary
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Delay discounting (DD) is quantified in human studies by determining the rate at which an individual discounts a delayed reward, while executive function (EF) is defined as the set of cognitive processes that are responsible for helping individuals manage life tasks and achieve goals. This research will attempt to reduce DD via EF training in a population of mid-life individuals with risk factors established during early-life disadvantage.
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Detailed Description
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Delay discounting (DD) is quantified in human studies by determining the rate at which an individual discounts a delayed reward, typically assessed by having subjects choose between a rewards available immediately and a larger reward available following a delay. For the purpose of this study, the investigators define executive function (EF) as the set of cognitive processes that are responsible for helping individuals manage life tasks and achieve goals (e.g., planning, working memory).
The approach of targeting preference for immediate rewards (exhibited by elevated DD) is highly innovative. Multiple studies provide compelling evidence that strengthening EF may decrease DD. Extensive literature indicates that many negative health and financial consequences suffered in mid-life are linked to adversity and disadvantage during early developmental periods of life. By targeting a mechanism of various negative aging-related outcomes (elevated DD), the proposed research may have the novel impact on broadly remediating the health and wellness of mid-life individuals at increased risk for poor consequences due to early-life disadvantage.
This research will attempt to reduce Delay Discounting via Executive Functioning training in a population of mid-life individuals with risk factors established during early-life disadvantage. DD, EF, and associated health behaviors/outcomes will be assessed at baseline, following training, and at 3- and 6-month follow-up. Participants will receive Active EF training, or Control training. Given the established effect of Active training in reducing DD in stimulant-dependent individuals, the study team expect reductions in DD, improvements in EF, and improvements in associated health behaviors/outcomes following Active training and at follow-up, with no improvements in the Control group.
Conditions
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Study Design
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RANDOMIZED
FACTORIAL
TREATMENT
SINGLE
Study Groups
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Active Training (AT) Group
Participants will complete four computerized training programs to improve executive function (EF), including Sequenced Recall of Digits - Auditory, Sequenced Reverse Recall of Digits - Auditory, Sequenced Recall of Words - Visual, Verbal Memory - Visual.
Sequenced Recall of Digits--Auditory
Auditory digit sequence AT memory component.
Sequenced Reverse Recall of Digits--Auditory
Reversed auditory digit sequence AT memory component.
Sequenced Recall of Words--Visual
Visual word sequence AT memory component
Verbal Memory--Visual
word recognition AT memory component
Control Training (CT) Group
Participants will complete the four computerized programs relating to executive function (EF), but will be provided with the answer (i.e., without memory requirements). That is, participants in the control condition will not be asked to engage their cognitive functions.
No interventions assigned to this group
Interventions
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Sequenced Recall of Digits--Auditory
Auditory digit sequence AT memory component.
Sequenced Reverse Recall of Digits--Auditory
Reversed auditory digit sequence AT memory component.
Sequenced Recall of Words--Visual
Visual word sequence AT memory component
Verbal Memory--Visual
word recognition AT memory component
Eligibility Criteria
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Inclusion Criteria
* Participants willing to participate in the 5-7 week program
Exclusion Criteria
* Participants with any significant medical or psychiatric condition which the training is not designed for (e.g., traumatic brain injury, dementia, significant learning disability, or schizophrenia)
* Participants with severe depression
40 Years
60 Years
ALL
Yes
Sponsors
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University of Maryland, Baltimore
OTHER
University of Florida
OTHER
Michigan State University
OTHER
National Institute on Aging (NIA)
NIH
University of Kansas
OTHER
Responsible Party
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Principal Investigators
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Richard Yi, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Kansas
Locations
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University of Kansas-Lawrence
Baltimore, Maryland, United States
Countries
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Central Contacts
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Facility Contacts
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References
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Collado A, Felton J, Grunevski S, Doran K, Yi R. Working Memory Training Reduces Cigarette Smoking Among Low-Income Individuals With Elevated Delay Discounting. Nicotine Tob Res. 2022 Apr 28;24(6):890-896. doi: 10.1093/ntr/ntac005.
Doran K, Collado A, Taylor H, Felton JW, Tormohlen KN, Yi R. Methods to Optimize Recruitment, Participation, and Retention Among Vulnerable Individuals Participating in a Longitudinal Clinical Trial. Res Theory Nurs Pract. 2021 Feb 1;35(1):24-49. doi: 10.1891/RTNP-D-19-00039.
Felton JW, Collado A, Ingram KM, Doran K, Yi R. Improvement of Working Memory is a Mechanism for Reductions in Delay Discounting Among Mid-Age Individuals in an Urban Medically Underserved Area. Ann Behav Med. 2019 Oct 7;53(11):988-998. doi: 10.1093/abm/kaz010.
Other Identifiers
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STUDY00143274
Identifier Type: -
Identifier Source: org_study_id
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