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Dual-task Training for Function in MCI

NCT ID: NCT04059705

Last Updated: 2023-11-30

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

17 participants

Study Classification

INTERVENTIONAL

Study Start Date

2023-04-04

Study Completion Date

2023-09-17

Brief Summary

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Mild cognitive impairment (MCI) is an intermediate stage between the expected cognitive decline of normal aging and severe dementia associated with Alzheimer's disease (AD). In the United States about 20% of older adults have MCI. Loss of cognitive function in aging can have far-reaching and devastating impacts on functional status, independence, and quality of life. Unfortunately, the therapeutic options to slow progression of cognitive decline in aging are limited. Dual-task training; that which involves simultaneous cognitive and motor challenges, is a high-impact potential therapy to slow progressive loss of both motor and cognitive function in aging. The purpose of this trial is to examine the feasibility and therapeutic impact of a novel dual-task physical activity intervention on executive and motor functions among adults, 65 years or older, who have MCI. the investigative team anticipates that findings from this trial will inform development of larger community-based studies focused on improving function and ability to maintain independence in older age.

Detailed Description

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Mild cognitive impairment (MCI) is an intermediate stage between the expected cognitive decline of normal aging and severe dementia associated with Alzheimer's disease (AD). In the United States about 20% of older adults have MCI, and approximately 15% per year of those with MCI will progress to AD. With our rapidly aging society, we are approaching a public health crisis for which we are not fully prepared. Impaired cognitive function in aging can have far-reaching and devastating impacts on functional status, ability to maintain independence, and overall quality of life. Unfortunately, the therapeutic options to slow progression of cognitive decline in aging are limited.

Dual-task training that involves simultaneous cognitive and motor challenges improves certain domains of both cognitive and motor function in older adults with MCI. However, we do not yet know the optimal methods of delivering this high-impact potential therapy in community-based settings with unique limitations and strengths. Therefore, the aims are to; 1) test the feasibility of conducting a community-based dual-task (thinking while exercising) physical activity intervention among adults, 65 years or older, with MCI; and 2) examine the impact of dual-task training on attention and motor function among adults, 65 years or older, with MCI.

To accomplish these aims the investigators will conduct an 12-week, dual-task training program using the SmartFit Multisensory Fitness System (Oxnard, CA) among older adults with MCI. Our group-based training program involves two 1-hour training sessions per week, designed to simultaneously engage the mind and body, while promoting self-efficacy. Attention and motor function will be assessed prospectively.

The investigators anticipate that findings from this trial will inform development of methods to bring evidence-based, non-invasive therapies into communities in need, in order to preserve function, independence, and quality of life well into older age.

Conditions

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Mild Cognitive Impairment

Keywords

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motor function cognitive attention dual-task physical activity cognition older adult mild cognitive impairment

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

This study utilizes a one-group design with repeated measures.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Dual-Task Intervention

This study arm will receive the dual-task training program.

Group Type EXPERIMENTAL

Dual-Task Training

Intervention Type BEHAVIORAL

The ThinkFIT intervention will involve two days per week participation in simultaneous cognitive and motor training activities, facilitated by the SMARTFit Multisensory FItness System.

Interventions

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Dual-Task Training

The ThinkFIT intervention will involve two days per week participation in simultaneous cognitive and motor training activities, facilitated by the SMARTFit Multisensory FItness System.

Intervention Type BEHAVIORAL

Other Intervention Names

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ThinkFIT Intervention, SMARTFit Multisensory Fitness System

Eligibility Criteria

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Inclusion Criteria

* 65 years of age or older
* Male or female
* Mild (23 - 26 points) cognitive impairment as screened by the Montreal Cognitive Assessment
* Having no absolute contraindications to non-physician supervised exercise as guided by the American College of Sports Medicine and Centers for Disease Control and Prevention.

Exclusion Criteria

* Having any condition that prevents safe participation in non-physician supervised exercise as screened using the Physical Activity Readiness Questionnaire for Older Adults
* Blood pressure \>180 mmHg systolic or 100 mmHg diastolic at baseline
* Presence of severe illness or disability
* Lower body amputation
* Cognitive Impairment beyond mild level, preventing provision of informed consent.
Minimum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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State University of New York at Buffalo

OTHER

Sponsor Role lead

Responsible Party

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Nikhil Satchidanand

Assistant Professor of Medicine

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Nikhil Satchidanand, PhD

Role: PRINCIPAL_INVESTIGATOR

University at Buffalo, State University of New York

Locations

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Buffalo-Niagara YMCA

Buffalo, New York, United States

Site Status

Countries

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United States

Other Identifiers

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STUDY00003525

Identifier Type: -

Identifier Source: org_study_id