Non-pharmacological Interventions on Cognitive Functions in Older People With Mild Cognitive Impairment
NCT ID: NCT03545152
Last Updated: 2019-06-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
192 participants
INTERVENTIONAL
2015-08-01
2018-07-31
Brief Summary
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Detailed Description
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Background. Mild cognitive impairment (MCI) is a common clinical syndrome that identifies people at high risk of developing dementia, and the prevalence range from 7.7 to 51.7%. Although treatments for MCI are currently unavailable, preliminary evidence has identified potential neuro-protective effects of exercise program and cognitive rehabilitation, which may lead to improved outcomes. However, the design and delivery of an appropriate program for people with MCI is challenging for having physical, psychological, cognitive, and social barriers.
Design. A prospective randomized control trial. We developed a Physical activity stage-matched intervention (SMI) (1st year), cognitive rehabilitation (2nd year) and New lifestyle program
Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
SINGLE
Study Groups
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comparison group
No procedure conducted between the pre- and the post-test evaluations, and they received an abridged version of the training after the post-test session.
No interventions assigned to this group
exercise group
The exercise program will include instructions on how to read the program, complete the activities, record their sessions, and exercise safely at first day. To promote incorporating exercising in their daily life routine during the 24-week period, we provided 2 group-based (5-8 participants with 2 instructors at community centers, 60' each) and one home-based (with the exercise program VCD and manual to bring home, 30') exercise program.
Exercise
Prescription exercise: frequency, intensity, type, time, and progression (FITT-PRO).
150 min/week (the intensity will be moderate). exercise routine: warming up, resistance training and aerobic exercise training(range of motion and flexibility exercises)
New life-style
Combination of exercise and cognitive interventions
cognitive training group
Consisted of 12 weekly sessions, lasting 60-90 minutes in groups of 5-8 participants, and 3 monthly boost sessions (to review the strategies and practice solving problems as well). The main strategy was to use cognitive rehabilitation strategies to promote generalization in this process to improve memory and behavior.
Cognitive training
Cognitive training intervention consisted of 12 weekly sessions, lasting 60-90 minutes in groups of 5-8 participants, and 3 monthly boost sessions (to review the strategies and practice solving problems as well). The main strategy was to use cognitive rehabilitation strategies to promote generalization in this process to improve memory and behavior.
New life-style
Combination of exercise and cognitive interventions
Interventions
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Exercise
Prescription exercise: frequency, intensity, type, time, and progression (FITT-PRO).
150 min/week (the intensity will be moderate). exercise routine: warming up, resistance training and aerobic exercise training(range of motion and flexibility exercises)
Cognitive training
Cognitive training intervention consisted of 12 weekly sessions, lasting 60-90 minutes in groups of 5-8 participants, and 3 monthly boost sessions (to review the strategies and practice solving problems as well). The main strategy was to use cognitive rehabilitation strategies to promote generalization in this process to improve memory and behavior.
New life-style
Combination of exercise and cognitive interventions
Eligibility Criteria
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Inclusion Criteria
* MMSE score\<16, 21 or 24, based on their years of education (illiterate, 6 or \>9 years, respectively, Yeh et al., 2000), but needed \>13 or objective memory impairment: AQ\>5 or at least one item of IADL dependence
* able to carry out activities in daily life
Exclusion Criteria
* depression or dementia diagnosis
65 Years
ALL
No
Sponsors
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Tzu-Ting Huang
OTHER
Responsible Party
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Tzu-Ting Huang
Professor, School of Nursing
Other Identifiers
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103-7443B
Identifier Type: -
Identifier Source: org_study_id
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