Multi-domain Online Therapeutic Investigation Of Neurocognition (MOTION)
NCT ID: NCT05217849
Last Updated: 2025-12-23
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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ACTIVE_NOT_RECRUITING
NA
80 participants
INTERVENTIONAL
2022-02-15
2026-06-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
SINGLE
Study Groups
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Tai Chi
Participants will engage in 60-minute Tai Chi classes twice a week for 12 weeks. The classes will be live-streamed over the internet. Tai Chi is an ancient Chinese system of gentle physical exercise and stretching. It involves a series of movements performed in a slow, focused manner and accompanied by deep breathing.
Tai Chi
Tai Chi is an ancient Chinese form of exercise/martial art that involves a series of movements performed in a slow, focused manner and accompanied by deep breathing.
Gentle, Mindful Movement
Participants will engage in a gentle, mindful movement class twice a week for 12 weeks. The classes will be one hour long and will be live-streamed over the internet. The mindful movement classes will combine elements from a wide range of Eastern and Western exercise modalities, including occupational therapy, physical therapy, yoga, tai chi, Feldenkrais, Rosen Method, dance movement therapy and mindfulness meditation.
Preventing Loss of Independence through Exercise (PLIE)
PLIE is a gentle, mindful movement exercise program that integrates elements of Eastern and Western exercise modalities to develop mindful body awareness and enhance social connection.
Health and Wellness Education
Participants will engage in bi-weekly 60 minute sessions of Health and Wellness Education classes. The classes will be held on-line for 12 weeks.
Health and Wellness Education
This on-line class will consist of hour-long lectures/talks about various topics related to healthy aging and wellness.
Interventions
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Tai Chi
Tai Chi is an ancient Chinese form of exercise/martial art that involves a series of movements performed in a slow, focused manner and accompanied by deep breathing.
Preventing Loss of Independence through Exercise (PLIE)
PLIE is a gentle, mindful movement exercise program that integrates elements of Eastern and Western exercise modalities to develop mindful body awareness and enhance social connection.
Health and Wellness Education
This on-line class will consist of hour-long lectures/talks about various topics related to healthy aging and wellness.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* subjective cognitive complaints, defined as self-experienced persistent decline in cognitive capacity in comparison with a previously normal status and unrelated to an acute event
* Montreal Cognitive Assessment (MoCA) score suggestive of Mild Cognitive Impairment (MCI) status (i.e., \< 26)
* English language fluency
* Wireless internet connection at home
* Willingness to travel to the San Francisco VA in northern California or UCLA in southern California for in-person assessments at baseline, after the 12-week interventions, and at the 36-week follow-up
* Capacity to provide informed consent or legally authorized representative consent and participant assent.
Exclusion Criteria
* disabilities that prevent participation in on-line movement classes (e.g., primarily use wheel-chair, severe visual impairment that would limit ability to observe instructor's movement on screen or severe hearing impairment that would limit ability to hear instructor's directions)
* insufficient English proficiency
* limited life expectancy (i.e., enrolled in hospice, metastatic cancer)
* plan to travel for \> 1 week during 12-week intervention period
* diagnosis of dementia per the DSM-5
* MoCA score suggestive of dementia (i.e., \<17)
* started dementia medication (cholinesterase inhibitor or memantine) in past 3 months or plans to start dementia medication during study period
* planning to start/change any psychoactive medication during study period
* current participation in another research study
* contraindications to magnetic resonance imaging (MRI), including claustrophobia severe enough to prevent MRI examination, presence of ferrometallic objects in the body that would interfere with MRI examination and/or cause a safety risk (e.g., pacemakers, implanted stimulators, pumps)
* prior or current training in with Tai Chi, PLIE, or other mind-body practices
55 Years
ALL
No
Sponsors
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San Francisco VA Health Care System
FED
University of California, Los Angeles
OTHER
United States Department of Defense
FED
CDMRP
UNKNOWN
University of California, San Francisco
OTHER
Responsible Party
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Principal Investigators
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Linda L Chao, PhD
Role: PRINCIPAL_INVESTIGATOR
University of California, San Francisco & SFVAHCS
Locations
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VA Health Care System
San Francisco, California, United States
Countries
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References
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Chao LL, Barnes DE, Chesney MA, Mehling WE, Lee JA, Benjamin C, Lavretsky H, Ercoli L, Siddarth P, Narr KL. Multi-domain Online Therapeutic Investigation Of Neurocognition (MOTION) - A randomized comparative-effectiveness study of two remotely delivered mind-body interventions for older adults with cognitive decline. Contemp Clin Trials. 2025 Feb;149:107811. doi: 10.1016/j.cct.2025.107811. Epub 2025 Jan 12.
Other Identifiers
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CDMRP - AZ160019
Identifier Type: OTHER_GRANT
Identifier Source: secondary_id
21-33507
Identifier Type: -
Identifier Source: org_study_id