Assessment of LTP-like Pain Amplification in Chronic Low Back Pain Patients
NCT ID: NCT03362827
Last Updated: 2017-12-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
50 participants
OBSERVATIONAL
2018-03-01
2018-12-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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OTHER
CROSS_SECTIONAL
Study Groups
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Chronic low back pain patients
People must have experienced low back pain for at least 3 months and have reported a minimal pain level of 30 (pain threshold) on the 0-100 pain numerical rating scale (NRS) in the last 7 days.
Chronic low back pain patients
People must have experienced low back pain for at least 3 months and have reported a minimal pain level of 30 (pain threshold) on the 0-100 pain numerical rating scale (NRS) in the last 7 days.
Subjects without chronic low back pain
Participants must not have presented episodes of low back pain for more than 7 days in the last 12 months.
Subjects without chronic low back pain
These participants must not have presented episodes of low back pain for more than 7 days in the last 12 months.
Interventions
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Chronic low back pain patients
People must have experienced low back pain for at least 3 months and have reported a minimal pain level of 30 (pain threshold) on the 0-100 pain numerical rating scale (NRS) in the last 7 days.
Subjects without chronic low back pain
These participants must not have presented episodes of low back pain for more than 7 days in the last 12 months.
Eligibility Criteria
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Inclusion Criteria
* People must have experienced low back pain for at least 3 months and have reported a minimal pain level of 30 (pain threshold) on the 0-100 pain numerical rating scale (NRS) in the last 7 days.
* Age 21-80 years old.
* These participants must not have presented episodes of low back pain for more than 7 days in the last 12 months.
Exclusion Criteria
* Patients were excluded if they had taken pain medications on the day of the assessment or if they had serious spinal pathologies, such as fractures, tumors or inflammatory diseases, such as ankylosing spondylitis, nerve root compromise confirmed by clinical neurological tests or severe cardiorespiratory diseases. Those who were pregnant, patients with cancer and those with a cardiac pacemaker were also excluded.
2. Healthy volunteers.
* Age below 21 or over 80 years old.
* These participants have presented episodes of low back pain for more than 7 days in the last 12 months.
20 Years
60 Years
ALL
Yes
Sponsors
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Peking University People's Hospital
OTHER
Responsible Party
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Liu Chenjun
Department of Spine Surgery
Principal Investigators
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Chenjun Liu, Ph.D.
Role: PRINCIPAL_INVESTIGATOR
Peking University People's Hospital
Central Contacts
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References
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Biurrun Manresa JA, Morch CD, Andersen OK. Long-term facilitation of nociceptive withdrawal reflexes following low-frequency conditioning electrical stimulation: a new model for central sensitization in humans. Eur J Pain. 2010 Sep;14(8):822-31. doi: 10.1016/j.ejpain.2009.12.008. Epub 2010 Jan 27.
Mouraux A, Iannetti GD, Plaghki L. Low intensity intra-epidermal electrical stimulation can activate Adelta-nociceptors selectively. Pain. 2010 Jul;150(1):199-207. doi: 10.1016/j.pain.2010.04.026. Epub 2010 May 26.
Morch CD, Hennings K, Andersen OK. Estimating nerve excitation thresholds to cutaneous electrical stimulation by finite element modeling combined with a stochastic branching nerve fiber model. Med Biol Eng Comput. 2011 Apr;49(4):385-95. doi: 10.1007/s11517-010-0725-8. Epub 2011 Jan 5.
Melzack R. The short-form McGill Pain Questionnaire. Pain. 1987 Aug;30(2):191-197. doi: 10.1016/0304-3959(87)91074-8.
Xia W, Morch CD, Andersen OK. Test-Retest Reliability of 10 Hz Conditioning Electrical Stimulation Inducing Long-Term Potentiation (LTP)-Like Pain Amplification in Humans. PLoS One. 2016 Aug 16;11(8):e0161117. doi: 10.1371/journal.pone.0161117. eCollection 2016.
Other Identifiers
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BackpainLTP
Identifier Type: -
Identifier Source: org_study_id