Objective Markers of Pain Perception in Humans

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

21 participants

Study Classification

INTERVENTIONAL

Study Start Date

2014-06-04

Study Completion Date

2018-02-28

Brief Summary

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Determine objective markers of pain perception remains a major scientific and medical issue. Various tools have been proposed to objectify pain, but their adaptability to different clinical contexts are limited. Our working hypothesis considers that the research for markers of immediate pain perception should be based on an electrophysiological approach, based on the combined analysis of EEG and autonomic responses.

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Detailed Description

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This project aims to study the cortical and autonomic responses induced by tonic painful stimulation compared to those induced by comparable sensory and stressful stimulations, by combining high density EEG, cutaneous sympathetic, cardiovascular and pupillary recordings.

Conditions

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Healthy

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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EEG responses

The study compares electroencephalographical responses (EEG) to painful stimuli tonic to those evoked by non-painful stimuli and with or without virtual reality

Group Type OTHER

Painful tonic stimuli

Intervention Type OTHER

non-painful stimuli

Intervention Type OTHER

Interventions

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Painful tonic stimuli

Intervention Type OTHER

non-painful stimuli

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Affiliate or beneficiary of social security
* Signature of consent

Exclusion Criteria

* History of cardiovascular disease (vagal syncope, hypertension, etc ...), renal, metabolic (diabetes ...), psychiatric (depression, etc ...) or neurological (seizure, etc ...) syndromes;
* Reynaud's syndrome;
* Raynaud's disease;
* Acrocyanosis;
* Known rhythm disorders;
* Participation at the same time in another clinical trial;
* Taking a medical treatment;
* Suffering from acute (complaint of pain in the week before the test) or chronic pain,
* Allergic to conductive gel for electrodes.

Minimum Eligible Age

18 Years

Maximum Eligible Age

35 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes