Magnetic Resonance Imaging Diffusion Tensor Tractography for Early Osteoarthritis Assessment

NCT ID: NCT03181425

Last Updated: 2017-07-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

8 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-10-31

Study Completion Date

2017-06-30

Brief Summary

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The aim of this study is the evaluation of new MRI tractography maps for early knee osteoarthritis assessment.

Detailed Description

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Knee osteoarthritis (OA) is a common and chronic degenerative disease of the articular cartilage. Despite recent progress in the field of cartilage imaging, no routinely used clinical imaging modality has the ability to evaluate and monitor changes in cartilage degeneration.

More and more studies report the benefits of Magnetic Resonance (MR) diffusion tensor imaging (DTI) in the study of early knee osteoarthritis and in particular the new MRI contrasts generating the Track Weighted Imaging (TWI) technique.

This observationnal, pilot, prospective, unrandomized and uncontrolled study aim to evaluate, for the first time, the new MRI tractography maps for the assessment of early knee osteoarthritis. This study doesn't modify the medical care of the patient.

Conditions

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Knee Osteoarthritis

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Imaging assessment

All subject of the study have a knee osteoarthritis (OA) and are going to have a knee prosthetic surgery with cartilage excision. Imaging measurements are conducted on human cartilage samples (2 samples per patient are selected : healthy and severely degraded).

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

Over 18 years of age Knee prosthetic surgery indication with cartilage excision

Exclusion Criteria

Refusal to sign a non-objection form
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Clinical Investigation Centre for Innovative Technology Network

NETWORK

Sponsor Role collaborator

University Hospital, Grenoble

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Alexandre Moreau-Gaudry, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Clinical Investigation Centre for Innovative Technology Network, University Hopital, Grenoble

Locations

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Orthopedic Surgery Department, University Hopital Grenoble Alpes

Grenoble, , France

Site Status

Countries

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France

Related Links

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http://www.cic-it.fr/cic-it-grenoble.php

Clinical Investigation Centre for Innovative Technology Network website

Other Identifiers

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DCIC1614

Identifier Type: -

Identifier Source: org_study_id

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