fMRI and Central Sensitization in Chronic Knee Osteoarthritis. A Pre and Post TKR Study
NCT ID: NCT03126279
Last Updated: 2017-04-24
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
50 participants
OBSERVATIONAL
2015-08-31
2017-08-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Preoperative Chronic Knee OA Patients
Patients will be recruited from orthopaedic preoperative clinics from those awaiting total knee replacement surgery.
Total Knee Replacement Surgery
All chronic knee osteoarthritis patients will be recruited as they are on the NHS waiting list for a total knee replacement. Only this group will undergo the procedure
Healthy Volunteers
Healthy volunteers will be recruited that are aged match to our OA patient cohort so meaningful comparisons regarding brain activity and pain sensitisation characteristics can be assessed.
No interventions assigned to this group
Interventions
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Total Knee Replacement Surgery
All chronic knee osteoarthritis patients will be recruited as they are on the NHS waiting list for a total knee replacement. Only this group will undergo the procedure
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Unilateral Knee OA No previous knee surgery Able to give informed consent Age \> 40 years
\- Healthy Volunteers Group
No OA or knee pain Able to give informed consent Age \> 40 years
Exclusion Criteria
Major medical, psychiatric, neurological Cx Other chronic pain condition (fibromyalgia) Contraindications to MRI Active Cancer Neuropathic drug treatment
-Healthy Volunteers Group
Pregnancy Lower limb pain or previous knee surgery Contraindications to MRI Active Cancer Major medical, psychiatric, neurological condition
40 Years
ALL
Yes
Sponsors
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Aalborg University
OTHER
Medical Research Council
OTHER_GOV
Arthritis Research UK
OTHER
Royal College of Surgeons of Edinburgh
OTHER
University of Nottingham
OTHER
Responsible Party
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Principal Investigators
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Dorothee P Auer, PhD
Role: PRINCIPAL_INVESTIGATOR
The University of Nottingham
Locations
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Academic Division of Trauma, Orthopaedics and Sports Medicine
Nottingham, Nottinghamshire, United Kingdom
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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10093
Identifier Type: -
Identifier Source: org_study_id
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