The Relationship Between Chronic OA Pain and Cognition Deficits in OA Patients.
NCT ID: NCT05570240
Last Updated: 2022-10-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
60 participants
OBSERVATIONAL
2019-08-07
2021-04-22
Brief Summary
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1. If pain characteristics affect cognitive functions in severe knee OA patients?
2. If concentration of neuroinflammation mediators were raised in severe knee OA patients with comparing with control group participants?
Participants will receive pain and cognition questionnaire before surgery and their blood and CSF will be collected for further analysis of neuroinflammation mediators.
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Detailed Description
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Besides ongoing pain in chronic knee OA is characterized by increased brain activity in limbic-affective regions thus providing novel evidence for a strong emotional component of arthritis pain. There are feedback loops exist between pain, emotion and cognition. How is the role of BDNF in such loop? The objective of the study was the evaluation of association between pain characteristics and cognitive functions in severe knee OA patients. Besides, we will try to explore the possible mechanisms by which chronic OA like pain develops to cognitive deficits in animal models. The relationship between BDNF levels in body fluids (serum and CSF) and pain characteristics and cognitive function was also evaluated in the whole sample.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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OA group
Knee osteoarthritis patients who were scheduled to receive elective total knee replacement surgery which need spinal anesthesia.
No interventions assigned to this group
Control group
Control group patients were scheduled to receive elective general surgery or urological surgery with spinal anesthesia.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Age is more than 20 years old.
* American Society of Anesthesiologists (ASA) class I-III.
Exclusion Criteria
* Age is lesser than 20 years old.
* Autoimmune diseases.
* Previous knee injury or infection history.
* Brain region disease ex: stroke or brain tumor...etc.
* Mild cognitive impairment, dementia or other neurodegenerative diseases.
* Cancer.
* With other chronic pain.
20 Years
86 Years
ALL
No
Sponsors
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Kaohsiung Veterans General Hospital.
OTHER
Responsible Party
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Chun-Hsien Wen
Physician
Principal Investigators
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Chun-Hsien Wen, Physician
Role: PRINCIPAL_INVESTIGATOR
Kaohsiung Veterans General Hospital.
Chen-Hsiu Chen, Physician
Role: STUDY_DIRECTOR
Kaohsiung Veterans General Hospital.
Yuan-Yi Chia, Director
Role: STUDY_DIRECTOR
Kaohsiung Veterans General Hospital.
Chih-Chi Tsai, RA
Role: STUDY_CHAIR
Kaohsiung Veterans General Hospital.
Locations
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Kaohsiung Veterans General Hopital
Kaohsiung City, Zuoying Dist, Taiwan
Countries
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References
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Zhang Y, Jordan JM. Epidemiology of osteoarthritis. Clin Geriatr Med. 2010 Aug;26(3):355-69. doi: 10.1016/j.cger.2010.03.001.
Kyrkanides S, Tallents RH, Miller JN, Olschowka ME, Johnson R, Yang M, Olschowka JA, Brouxhon SM, O'Banion MK. Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice. J Neuroinflammation. 2011 Sep 7;8:112. doi: 10.1186/1742-2094-8-112.
Huang SW, Wang WT, Chou LC, Liao CD, Liou TH, Lin HW. Osteoarthritis increases the risk of dementia: a nationwide cohort study in Taiwan. Sci Rep. 2015 May 18;5:10145. doi: 10.1038/srep10145.
Li X, Tong Q, Gao J, Liu C; Alzheimer's Disease Neuroimaging Initiative; Liu Y. Osteoarthritis Was Associated With a Faster Decline in Hippocampal Volumes in Cognitively Normal Older People. Front Aging Neurosci. 2020 Aug 14;12:190. doi: 10.3389/fnagi.2020.00190. eCollection 2020.
Wu L, Wang X, Ye Y, Liu C. Association of Osteoarthritis With Changes in Structural Neuroimaging Markers Over Time Among Non-demented Older Adults. Front Aging Neurosci. 2021 Aug 10;13:664443. doi: 10.3389/fnagi.2021.664443. eCollection 2021.
Clark AK, Malcangio M. Fractalkine/CX3CR1 signaling during neuropathic pain. Front Cell Neurosci. 2014 May 7;8:121. doi: 10.3389/fncel.2014.00121. eCollection 2014.
Grace PM, Hutchinson MR, Maier SF, Watkins LR. Pathological pain and the neuroimmune interface. Nat Rev Immunol. 2014 Apr;14(4):217-31. doi: 10.1038/nri3621. Epub 2014 Feb 28.
Montague K, Malcangio M. The therapeutic potential of targeting chemokine signalling in the treatment of chronic pain. J Neurochem. 2017 May;141(4):520-531. doi: 10.1111/jnc.13927. Epub 2017 Feb 24.
Subbarayan MS, Joly-Amado A, Bickford PC, Nash KR. CX3CL1/CX3CR1 signaling targets for the treatment of neurodegenerative diseases. Pharmacol Ther. 2022 Mar;231:107989. doi: 10.1016/j.pharmthera.2021.107989. Epub 2021 Sep 4.
Cappoli N, Tabolacci E, Aceto P, Dello Russo C. The emerging role of the BDNF-TrkB signaling pathway in the modulation of pain perception. J Neuroimmunol. 2020 Dec 15;349:577406. doi: 10.1016/j.jneuroim.2020.577406. Epub 2020 Sep 24.
Malfait AM, Miller RE, Block JA. Targeting neurotrophic factors: Novel approaches to musculoskeletal pain. Pharmacol Ther. 2020 Jul;211:107553. doi: 10.1016/j.pharmthera.2020.107553. Epub 2020 Apr 18.
Tang J, Bair M, Descalzi G. Reactive Astrocytes: Critical Players in the Development of Chronic Pain. Front Psychiatry. 2021 May 28;12:682056. doi: 10.3389/fpsyt.2021.682056. eCollection 2021.
Provided Documents
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Document Type: Study Protocol
Other Identifiers
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VGHKS19-CT2-21
Identifier Type: -
Identifier Source: org_study_id
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