Can 3D Kinematic Parameters Assess the Symptomatic and Functional Severity of KOA?

NCT ID: NCT03011112

Last Updated: 2017-03-03

Basic Information

• Recruitment Status: COMPLETED
• Total Enrollment: 186 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2017-01-02
• Study Completion Date: 2017-02-28

Brief Summary

There is little study focusing on kinematic parameters in the assessment of the symptomatic and functional severity of knee osteoarthritis (KOA). The purpose of this study is to evaluate the correlations between kinematic parameters and the severity of symptoms and functions in patients with KOA.

Conditions

Osteoarthritis,Knee

Study Design

• Observational Model Type: CASE_CONTROL
• Study Time Perspective: CROSS_SECTIONAL

Study Groups

KL 1

All patients (\>50 years) are classified to be Kellgrence/Lawrence grade 1 according to Kellgrence/Lawrence score.

Observational procedure

Intervention Type: PROCEDURE

All the patients will undergo a standard observational procedure: i) diagnosed with KOA; ii) take a radiographic examination (x-ray); iii) assessed by WOMAC; iv) take an physical examination to avoid other disease; iv) take a gait examination on a treadmill in barefoot.

KL 2

All patients (\>50 years) are classified to be Kellgrence/Lawrence grade 2 according to Kellgrence/Lawrence score.

Observational procedure

Intervention Type: PROCEDURE

All the patients will undergo a standard observational procedure: i) diagnosed with KOA; ii) take a radiographic examination (x-ray); iii) assessed by WOMAC; iv) take an physical examination to avoid other disease; iv) take a gait examination on a treadmill in barefoot.

KL 3

All patients (\>50 years) are classified to be Kellgrence/Lawrence grade 3 according to Kellgrence/Lawrence score.

Observational procedure

Intervention Type: PROCEDURE

All the patients will undergo a standard observational procedure: i) diagnosed with KOA; ii) take a radiographic examination (x-ray); iii) assessed by WOMAC; iv) take an physical examination to avoid other disease; iv) take a gait examination on a treadmill in barefoot.

KL 4

All patients (\>50 years) are classified to be Kellgrence/Lawrence grade 4 according to Kellgrence/Lawrence score.

Observational procedure

Intervention Type: PROCEDURE

All the patients will undergo a standard observational procedure: i) diagnosed with KOA; ii) take a radiographic examination (x-ray); iii) assessed by WOMAC; iv) take an physical examination to avoid other disease; iv) take a gait examination on a treadmill in barefoot.

Interventions

Observational procedure

All the patients will undergo a standard observational procedure: i) diagnosed with KOA; ii) take a radiographic examination (x-ray); iii) assessed by WOMAC; iv) take an physical examination to avoid other disease; iv) take a gait examination on a treadmill in barefoot.

Intervention Type: PROCEDURE

Eligibility Criteria

Inclusion Criteria

1. age> 50 years

2. body mass index<30;

3. confirmed radiographically and assessed according to KL score;

4. knee pain in their knees at least three months;

5. absolute medial compartment KOA according to atlas criteria13;

6. able to walk unaided

Exclusion Criteria

1. history of knee surgery;

2. Corticosteroid or Sodium Hyaluronate injection within 6 months;

3. neuropathic arthropathy or rheumatoid arthritis;

4. any other muscular or neurological diseases that affected the condition of the lower limbs;

5. any treatments or training (e.g. kneepad) to improve the symptoms of KOA;

6. history of foot/ankle/hip injury or disease;

7. unable to walk independently;

8. history of heart disease;

9. lateral KOA according to atlas criteria13;

10. body mass index> 30;

11. age> 90 years;

12. unable to finish the procedure

• Minimum Eligible Age: 50 Years
• Maximum Eligible Age: 90 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Medical Center of Assessment, Prevention and Treatment of Bone & Joint Diseases, Guangdong, China

OTHER

Sponsor Role: collaborator

The First Affiliated Hospital of Guangzhou Medical University

OTHER

Sponsor Role: collaborator

Guangzhou General Hospital of Guangzhou Military Command

OTHER

Sponsor Role: lead

Responsible Party

Yu Zhang

chief surgeon, associate professor

Responsibility Role: PRINCIPAL_INVESTIGATOR

Principal Investigators

Yu Zhang, PhD

Role: PRINCIPAL_INVESTIGATOR

Hospital of Orthopedics, Guangzhou General Hospital of Guangzhou Military Command, 111 Liuhua Road, Guangzhou 510010, China

Locations

Hospital of Orthopedics, Guangzhou General Hospital of Guangzhou Military Command

Guangzhou, Guangdong, China

Countries

China

Other Identifiers

GuangzhouGH003

Identifier Type: -

Identifier Source: org_study_id