Proprioceptive Fatigue Adaptation in Osteoarthritis

NCT ID: NCT06972186

Last Updated: 2025-05-14

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 20 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-06-01
• Study Completion Date: 2025-12-01

Brief Summary

This study aims to investigate the effects of fatigue induced by isokinetic exercise on passive and active joint position sense in postmenopausal women diagnosed with knee osteoarthritis (gonarthrosis). A healthy control group matched for age and sex will also be included for comparative analysis. Participants will undergo proprioceptive assessments before and after an isokinetic fatigue protocol. We hypothesize that (1) fatigue will impair both passive and active joint position sense in patients with gonarthrosis, (2) active joint position sense will be more affected than passive sense, and (3) the deterioration in proprioception will be greater in the gonarthrosis group compared to healthy controls.

Detailed Description

Osteoarthritis, particularly knee osteoarthritis (gonarthrosis), is a progressive musculoskeletal disease that severely affects lower extremity functions. Proprioceptive impairments in these patients can lead to altered motor control, reduced movement accuracy, and increased risk of falls. Fatigue may exacerbate these impairments by affecting sensory feedback from muscle spindles and joint receptors, which is critical for joint stability and motor control. In postmenopausal women, hormonal changes further compound muscle weakness and joint instability, highlighting the clinical importance of understanding proprioceptive changes following fatigue.

This experimental study will involve two groups: postmenopausal women with gonarthrosis and age-matched healthy controls. Participants will undergo an isokinetic fatigue protocol followed by assessments of passive and active joint position sense being more vulnerable. Understanding these changes will contribute to developing rehabilitation strategies focusing on proprioception and fatigue management.

We expect that isokinetic fatigue will impair proprioception, with active joint position

Conditions

Osteoarthritis of Knee; Proprioception; Isokinetic Test; Gonarthritis

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: NONE

Study Groups

Healthy Control

Age- and sex-matched postmenopausal women without knee pathology. Participants will perform the same passive and active joint position sense tests as the gonarthrosis group, before and after a control fatigue protocol using the Biodex system.

Group Type: ACTIVE_COMPARATOR

Fatigue Protocol + Joint Position Sense Testing

Intervention Type: DIAGNOSTIC_TEST

Groups will undergo an isokinetic fatigue protocol at 180°/s using a Biodex dynamometer. Passive and active joint position sense tests will be performed before and after fatigue.

Gonarthrosis Group

Postmenopausal women aged 50-65 with Kellgren-Lawrence Grade 2-3 knee osteoarthritis.

Participants will undergo an isokinetic fatigue protocol at 180°/s using a Biodex dynamometer. Passive and active joint position sense tests will be performed before and after fatigue.

Group Type: EXPERIMENTAL

Fatigue Protocol + Joint Position Sense Testing

Intervention Type: DIAGNOSTIC_TEST

Groups will undergo an isokinetic fatigue protocol at 180°/s using a Biodex dynamometer. Passive and active joint position sense tests will be performed before and after fatigue.

Interventions

Fatigue Protocol + Joint Position Sense Testing

Groups will undergo an isokinetic fatigue protocol at 180°/s using a Biodex dynamometer. Passive and active joint position sense tests will be performed before and after fatigue.

Intervention Type: DIAGNOSTIC_TEST

Eligibility Criteria

Inclusion Criteria

• Female, aged 50-65
• Postmenopausal
• Grade 2-3 knee osteoarthritis (Kellgren-Lawrence Scale) for OA group
• No lower extremity surgery in the last 6 months
• No neuromuscular or orthopedic condition affecting the lower extremities

Exclusion Criteria

• Severe balance disorders or vestibular disease
• Bilateral knee prosthesis or severe osteoporosis
• Lower extremity musculoskeletal injury in the last 6 months

• Minimum Eligible Age: 45 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: FEMALE
• Accepts Healthy Volunteers: Yes

Sponsors

Inonu University

OTHER

Sponsor Role: collaborator

Kocaeli Sağlık ve Teknoloji Üniversitesi

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Central Contacts

hatice sena cinarli, assistant professor

Role: CONTACT

haticesena.cinarli@kocaelisaglik.edu.tr

+905436093619

Ozan Uçar, Physical Therapist

Role: CONTACT

oznucr@hotmail.com

+905387497609

Other Identifiers

KOSTU-25-OA-01

Identifier Type: -

Identifier Source: org_study_id