Muscle Property, Alignment and Joint Loading in People With Knee Osteoarthritis

NCT ID: NCT03628508

Last Updated: 2021-09-16

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

40 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-03-01

Study Completion Date

2019-12-31

Brief Summary

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Knee osteoarthritis (KOA) is a common chronic painful musculoskeletal condition among older adults. It poses great challenge to the health care system due to its inability to be cured. Understanding factors associated with disease progression in KOA should assist the development of novel prevention/rehabilitation strategies. This study investigate factors including muscle properties, lower limb alignment and joint loading in patients with knee osteoarthritis before and after a six-week exercise program.

Detailed Description

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Conditions

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Osteoarthritis, Knee

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Exercise

Six-week exercise including stretching, strengthening, endurance and gait modification

Group Type EXPERIMENTAL

Exercise

Intervention Type OTHER

Comprehensive exercise program including strengthening, stretching, gait modification etc.

Interventions

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Exercise

Comprehensive exercise program including strengthening, stretching, gait modification etc.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

1. Age between 50-80
2. having radiographic tibiofemoral joint OA in the medial compartment defined as Kellgren and Lawrence grade = 2 to 3
3. having medial knee pain on most days of the month
4. having a minimum average pain score of 2 on an 11-point numerical rating scale in the past week while walking

Exclusion Criteria

1. having lateral tibiofemoral compartment osteophytes greater than the medial side.
2. having undergone intra-articular corticosteroid injection or knee surgery to either knee within the past 3 months
3. having a systemic arthritic condition (e.g., rheumatoid arthritis)
4. having a knee joint replacement or high tibial osteotomy in the past
5. having any other muscular, joint or neurological condition influencing lower limb function
6. unable to walk unaided
7. having low back, hip, ankle or foot pain \> 3 on numerical rating scale
8. having a body mass index (BMI) \>36 kg/ m2
Minimum Eligible Age

50 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Queen Mary Hospital, Hong Kong

OTHER

Sponsor Role collaborator

The Hong Kong Polytechnic University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Siu Ngor Fu, PhD

Role: PRINCIPAL_INVESTIGATOR

The Hong Kong Polytechnic University

Locations

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Queen Mary Hospital

Hong Kong, , Hong Kong

Site Status

Countries

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Hong Kong

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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HSEARS20170406003

Identifier Type: -

Identifier Source: org_study_id

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