Nutrition and Movement to Improve Quality of Life With Knee Osteoarthritis
NCT ID: NCT05955300
Last Updated: 2023-12-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
60 participants
INTERVENTIONAL
2024-01-06
2025-03-02
Brief Summary
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Detailed Description
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Factors that contribute to chronic low-grade inflammation include a nutrient overload, a metabolic surplus, pro-inflammatory cytokines and adipokines. Knee OA is the most common form of OA with prevalence rising with age peaked at around 50 years of age affecting more than 250 million people worldwide. Exercise therapy (ET) is an effective component of early treatment and is therefore recommended as a first line treatment. Good Life with osteoArthritis in Denmark (GLA:D®) represents an evidence-based treatment plan for knee OA and optimizes the implementation of ET. However, ET mainly addresses physical and functional deficits in patients with knee OA, but not the inflammatory processes. Due to the association of chronic low-grad inflammation with dietary patterns, nutrition plays a significant role in inflammation-related diseases. A plant-based, anti-oxidative and anti-inflammatory therapeutic diet helps to improve symptoms leading to improved quality of life. When implementing a therapeutic diet, it should be attractive for patients and regional needs should be considered. This might increase adherence to therapeutic diet and will have an environmental impact - the New Nordic Diet (NND) seems to fulfil these requirements. To our knowledge no study has examined the influence of NND on symptoms and QL in OA. Further, there is a lack of knowledge concerning the impact of exercise therapy AND nutrition therapy on symptoms and QL in patients with knee OA.
Aims
1. To evaluate the effect of a nutrition therapy combined with exercise therapy on QL in patients knee OA
2. To investigate the impact of a nutrition therapy combined with exercise therapy on symptoms, nutrition and inflammation status and joint function in patients with knee OA
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Training program and nutrition therapy
The intervention group receive the GLA:D® training program for 6 weeks and a nutrition therapy for 9 months.
Training program
The GLAD training program consists of neuromuscular exercises for the core, the knee and the hip muscles and patient education. The New Nordic Diet is a plant-based nutrition thats aims to reduce systematic low-grad inflammation.
Nutrition therapy
Nutrition therapy based on the New Nordic Diet
Training program
The control group receive GLA:D® training program for 6 weeks and general information regarding a healthy life style for 9 months.
Training program
The GLAD training program consists of neuromuscular exercises for the core, the knee and the hip muscles and patient education. The New Nordic Diet is a plant-based nutrition thats aims to reduce systematic low-grad inflammation.
Interventions
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Training program
The GLAD training program consists of neuromuscular exercises for the core, the knee and the hip muscles and patient education. The New Nordic Diet is a plant-based nutrition thats aims to reduce systematic low-grad inflammation.
Nutrition therapy
Nutrition therapy based on the New Nordic Diet
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* kognitive deficits
* internal, neurological and mental diseases
* drug and/or alcohol abuse
50 Years
75 Years
ALL
No
Sponsors
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University of Vienna
OTHER
Danube University Krems
OTHER
St. Pölten University of Applied Sciences
OTHER
Responsible Party
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Locations
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Sankt Pölten University of Applied Sciences
Sankt Pölten, Lower Austria, Austria
St. Poelten University of Applied Sciences
Sankt Pölten, , Austria
Countries
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Central Contacts
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Facility Contacts
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Gabriele Permoser
Role: primary
Birgit Bauer, Dr.
Role: backup
Barbara Wondrasch, PhD
Role: primary
Sabine Chmelar, MSc
Role: backup
References
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Hold E, Chmelar S, Aubram T, Leitner G, Nehrer S, Neubauer O, Wagner KH, Wondrasch B. Nutrition and movement to improve quality of life in patients with knee osteoarthritis: the NUMOQUA study protocol for a randomised controlled trial. Trials. 2024 Apr 9;25(1):245. doi: 10.1186/s13063-024-08048-2.
Other Identifiers
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NUMOQUA
Identifier Type: -
Identifier Source: org_study_id