Effect Of Aspirin Preoperative on Postoperative Cognitive Dysfunction In Elderly Patients Undergoing Knee Arthroplasty

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Total Enrollment

220 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-01-01

Study Completion Date

2020-06-30

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Studies have shown that the lifetime risk of developing symptomatic knee osteoarthritis is 40% in men and 47% in women; and the risk can be increased to 60% when the patient's BMI reaches 30 kg/m2. In this population, knee replacement is the most common, effective, and cost-effective method in all treatments with reducing pain, improving joint function and quality of life. Postoperative cognitive dysfunction (POCD) is a common complication in the elderly, and its incidence can reach 25-40% in major non-cardiac surgery. As for POCD can prolong hospital stay, increase mortality and morbidity, and increase social and economic burden, it is especially important for the prevention and treatment of POCD. However, The mechanism of POCD is still unclear. Studies suggest that it may involve inflammation and oxidative stress in the central nervous system. But for the elderly, they are in a state of low inflammatory response. At the same time, surgery and tourniquets also can trigger or aggravate inflammatory response. Once the inflammatory factors released into the blood circulation, they can act on the central nervous system in a variety of ways. As a result,elderly patients are more likely to develop POCD. In addition, some studies have shown that pain can also increase cognitive burden. Aspirin, its pharmacodynamic effects includes anti-inflammatory and analgesic effects which may have a certain effect on the prevention of POCD.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

The Relationship Between Chronic OA Pain and Cognition Deficits in OA Patients.

NCT05570240

Knee Osteoarthritis Neuroinflammatory Response

COMPLETED

Molecular Pathways Involved in Knee Pain

NCT04443452

Knee Osteoarthritis Knee Pain Chronic

COMPLETED

The Efficacy of Collaborative Patient Education on Total Knee Arthroplasty

NCT05346822

Knee Arthritis

COMPLETED NA

The Assessment of Postoperative Recovery in Elder Diabetic Patients

NCT01871012

Anesthesia Knee Osteoarthritis

UNKNOWN

Effects of Ischemic Preconditioning on Conditioned Pain Modulation and Heart Rate Variability in Knee Osteoarthritis

NCT05059652

Ischemic Preconditioning

COMPLETED NA

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Elderly patients undergoing knee replacement are more likely to develop POCD. The aim of this study is to determine the incidence of short-term POCD and long-term cognitive status in the elderly patients who use Aspirin atleast three months before knee replacement.And then, the study evaluates the effect of Aspirin on the incidence of postoperative delirium. In addition, it also shows the risk factors for POCD such as postoperative delirium, pain, C reactive protein and so on in the elderly patients who undergo knee replacement.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Elective Surgery Postoperative Cognitive Dysfunction Knee Arthroplasty

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Group Aspirin

The elderly patients who using Aspirin at least three months before operation were in the Group Aspirin

No interventions assigned to this group

Group Control

The elderly patients who not using Aspirin before operation were in the Group Control

No interventions assigned to this group

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Age more than 60 years old undergoing elective knee replacement with general anesthesia
* ASA score grade I-III
* Sign that informed consent is willing to participate in the study
* Can communicate in verbal
* The time of using aspirin is at least 3 months

Exclusion Criteria

* Central nervous system disease;
* Mental illness before or now;
* With using Antipsychotic treatment such as sedatives or antidepressants;
* With drug dependence;
* Severe visual, auditory, or motor impairment;
* Acute infection;
* Emergency surgery;
* Serious systemic diseases;
* Preoperative delirium and/ or cognitive dysfunction preoperative;
* History of hospitalization 3 months before surgery.
* Participating in other research

Minimum Eligible Age

60 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes