Integrative Chinese and Western Medicine for Knee Osteoarthritis

NCT ID: NCT07072442

Last Updated: 2025-07-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

NOT_YET_RECRUITING

Clinical Phase

NA

Total Enrollment

228 participants

Study Classification

INTERVENTIONAL

Study Start Date

2025-08-01

Study Completion Date

2028-07-31

Brief Summary

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This study aims to investigate if an integrated approach combining Traditional Chinese and Western medicine can better treat knee osteoarthritis. The goal is to see if this combined therapy can more effectively reduce pain severity and frequency, leading to an improved quality of life for KOA patients. Additionally, the study will explore the underlying mechanisms of pain and anti-inflammation related to KOA.

Detailed Description

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Conditions

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Knee Osteoarthristis

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

FACTORIAL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Western medicine

Western medicine treatment only

Group Type ACTIVE_COMPARATOR

Western Medicine

Intervention Type DRUG

Western medicine treatment only

Herbal medicine and acupuncture

Western medicine combined herbal medicine and acupuncture

Group Type EXPERIMENTAL

herbal medicine and acupuncture

Intervention Type PROCEDURE

Western medicine combined acupuncture and herbal medicine treatemnt

herbal medicine

Western medicine combined herbal medicine

Group Type EXPERIMENTAL

herbal medicine

Intervention Type DRUG

Western medicine combined herbal medicine

Acupuncture

western medicine combined acupuncture

Group Type EXPERIMENTAL

acupuncture

Intervention Type PROCEDURE

western medicine combined acupuncture

Interventions

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Western Medicine

Western medicine treatment only

Intervention Type DRUG

herbal medicine and acupuncture

Western medicine combined acupuncture and herbal medicine treatemnt

Intervention Type PROCEDURE

herbal medicine

Western medicine combined herbal medicine

Intervention Type DRUG

acupuncture

western medicine combined acupuncture

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Male or female aged above 18 years old
* Kellgren-lawrence grading scale ≥ II
* Numerical rating scale (NRS) ≥ 4

Exclusion Criteria

* History of bone tumor
* Pregnancy
* History of bilateral knee replacement
* Active infection
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Chang Gung Memorial Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Other Identifiers

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NMRPG8Q6021

Identifier Type: -

Identifier Source: org_study_id

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