Improved Pain Management in Knee Osteoarthritis-related Surgeries

NCT ID: NCT06124170

Last Updated: 2023-11-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

714 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-03-01

Study Completion Date

2023-03-02

Brief Summary

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In recent years, pain management coordinated with enhanced recovery after surgery (ERAS) has been widely applied and rapidly developed in orthopedics, showing promising prospects. Since 2016, our hospital has used a series of continuously improved pain management schemes for patients with knee OA who underwent total knee arthroplasty (TKA), unicompartmental knee arthroplasty (UKA), and high tibial osteotomy (HTO). Here, we retrospectively analyze these patients' clinical data to compare the effects of different pain intervention measures during the perioperative period on postoperative pain, functional exercise, hospital stay, and prognosis of the three surgical methods in an attempt to provide a feasible solution for pain management of these patients.

Detailed Description

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We retrospectively analyzed the clinical data of patients with knee osteoarthritis (OA) who received surgical treatment to provide a feasible solution for perioperative pain management of these patients. The medical records of 714 patients with knee OA who had undergone total knee arthroplasty (n=551), unicompartmental knee arthroplasty (n=92) and high tibial osteotomy (n=71) were retrospectively analyzed and the cases were divided into Groups A, B, and C, according to the continuously optimized pain management. Clinical data including anesthesia grade, surgery time, functional exercise, hospital stay, pain, emotion, complications and prognosis were compared.

Conditions

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Knee Osteoarthritis Total Knee Arthroplasty Unicompartmental Knee Arthroplasty High Tibial Osteotomy Pain Management

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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Total knee arthroplasty (TKA)

Total knee arthroplasty

Preoperative pain managment

Intervention Type PROCEDURE

propaganda and education on pain; Preemptive analgesia with celecoxib (200 mg bid) 2 days before surgery

Intraoperative pain managment

Intervention Type PROCEDURE

Squeeze to expel blood (tourniquet); Before skin suture, 20 mL 0.5% ropivacaine was given subcutaneously for local infiltration anesthesia;

Postoperative pain managment

Intervention Type PROCEDURE

The intravenous analgesia pump was placed until 48 h after surgery;On the second day after surgery, celecoxib (200 mg bid) was administered orally, and buprenorphine transdermal patch was applied externally until hospital discharge;FNB catheter was placed under the guidance of ultrasound and connected with an analgesic pump, the anesthesia lasted until 48 h after surgery ‡

Unicompartmental knee arthroplasty (UKA)

Unicompartmental knee arthroplasty

Preoperative pain managment

Intervention Type PROCEDURE

propaganda and education on pain; Preemptive analgesia with celecoxib (200 mg bid) 2 days before surgery

Intraoperative pain managment

Intervention Type PROCEDURE

Squeeze to expel blood (tourniquet); Before skin suture, 20 mL 0.5% ropivacaine was given subcutaneously for local infiltration anesthesia;

Postoperative pain managment

Intervention Type PROCEDURE

The intravenous analgesia pump was placed until 48 h after surgery;On the second day after surgery, celecoxib (200 mg bid) was administered orally, and buprenorphine transdermal patch was applied externally until hospital discharge;FNB catheter was placed under the guidance of ultrasound and connected with an analgesic pump, the anesthesia lasted until 48 h after surgery ‡

High tibial osteotomy (HTO)

High tibial osteotomy

Preoperative pain managment

Intervention Type PROCEDURE

propaganda and education on pain; Preemptive analgesia with celecoxib (200 mg bid) 2 days before surgery

Intraoperative pain managment

Intervention Type PROCEDURE

Squeeze to expel blood (tourniquet); Before skin suture, 20 mL 0.5% ropivacaine was given subcutaneously for local infiltration anesthesia;

Postoperative pain managment

Intervention Type PROCEDURE

The intravenous analgesia pump was placed until 48 h after surgery;On the second day after surgery, celecoxib (200 mg bid) was administered orally, and buprenorphine transdermal patch was applied externally until hospital discharge;FNB catheter was placed under the guidance of ultrasound and connected with an analgesic pump, the anesthesia lasted until 48 h after surgery ‡

Interventions

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Preoperative pain managment

propaganda and education on pain; Preemptive analgesia with celecoxib (200 mg bid) 2 days before surgery

Intervention Type PROCEDURE

Intraoperative pain managment

Squeeze to expel blood (tourniquet); Before skin suture, 20 mL 0.5% ropivacaine was given subcutaneously for local infiltration anesthesia;

Intervention Type PROCEDURE

Postoperative pain managment

The intravenous analgesia pump was placed until 48 h after surgery;On the second day after surgery, celecoxib (200 mg bid) was administered orally, and buprenorphine transdermal patch was applied externally until hospital discharge;FNB catheter was placed under the guidance of ultrasound and connected with an analgesic pump, the anesthesia lasted until 48 h after surgery ‡

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* first knee surgery were 50-80 years old had complete clinical and follow-up data

Exclusion Criteria

* American Society of Anesthesiologists Physical Status grade≥4 comorbidity with three or more systemic diseases long-term anxiety and depression, contraindications of painkillers, long-term alcoholism, or taking painkillers concomitant limb pain caused by spinal degeneration
Minimum Eligible Age

50 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Peng Liu

OTHER

Sponsor Role lead

Responsible Party

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Peng Liu

Professor

Responsibility Role SPONSOR_INVESTIGATOR

Locations

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Sichuan Provincial People's Hospital

Chengdu, Sichuan, China

Site Status

Countries

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China

Other Identifiers

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2023-414

Identifier Type: -

Identifier Source: org_study_id

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