Analysis of the Pathophysiological and Functional State of the Knee Joint
NCT ID: NCT06490770
Last Updated: 2025-07-17
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
25 participants
INTERVENTIONAL
2025-07-09
2027-04-30
Brief Summary
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Despite its significant impact, effective treatments for osteoarthritis that address its underlying causes are still lacking, focusing mainly on symptom management. Therefore, improving diagnostic and prognostic approaches is crucial to better understand its onset and progression.
MRI is a primary diagnostic tool for assessing the knee joint's pathophysiological state. It uses tissue-specific sequences to investigate joint homeostasis in detail, although it primarily provides insights into morphology, structure, and tissue composition rather than functional changes within the joint. This limitation is noteworthy because joint homeostasis involves complex interactions among biomechanical, structural, and biological processes, which are directly influenced by osteoarthritis.
Gait analysis provides valuable diagnostic information on joint function. By integrating sensor measurements and electronic systems with patient-specific musculoskeletal models derived from MRI morphometric data, it is possible to assess the forces and moments within the joint during specific movements.
Given that osteoarthritis affects the entire joint, employing multidisciplinary approaches can enhance diagnostic precision and provide insights into the progressive impact of degenerative conditions like osteoarthritis on joint health.
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Detailed Description
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Conditions
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Study Design
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NA
SINGLE_GROUP
DIAGNOSTIC
NONE
Study Groups
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group 1
Gait analysis, Magnetic Resonance Imaging
Gait analysis and Magnetic Resonance Imaging to investigate the functionality and the pathological condition of the knee, respectively
Interventions
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Gait analysis, Magnetic Resonance Imaging
Gait analysis and Magnetic Resonance Imaging to investigate the functionality and the pathological condition of the knee, respectively
Eligibility Criteria
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Inclusion Criteria
* Kellgren-Lawrence grade less than or equal to 2
* Arthroscopic evidence of cartilage tissue lesions
* Evidence of cartilage and/or meniscal tissue degeneration and/or subchondral bone marrow lesions
Exclusion Criteria
* Inability to provide informed consent
* Conditions or physical disorders incompatible with the use of MRI and electrical stimulation (implanted active and passive biomedical devices, epilepsy, severe venous insufficiency in the lower limbs)
18 Years
60 Years
ALL
No
Sponsors
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Istituto Ortopedico Rizzoli
OTHER
Responsible Party
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Stefano Zaffagnini
Full Professor Medicine and Surgery, University of Bologna
Locations
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IRCCS Istituto Ortopedico Rizzoli
Bologna, , Italy
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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Gait-MRI-Knee
Identifier Type: -
Identifier Source: org_study_id
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