Oxytocin's Effect on Attention Training

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-11-25

Study Completion Date

2018-12-30

Brief Summary

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This study aims to investigate oxytocin's effect on attentional bias training. Healthy participants will undergo a dot-probe task-based training to direct their attention away from negative stimuli (as compared to neutral). Effects of the training will be assessed using an eye-tracking anti-saccade task.

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Detailed Description

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In this study, a dot-probe task will be used to examine if subjects show an attentional bias towards negative stimuli and whether the bias can be modified using a subsequent attentional bias training. During this training participants learn to direct their attention away from threatening stimuli. In a between-subject placebo controlled design participants will receive either intranasal oxytocin or placebo before the training to examine whether oxytocin could facilitate the effects of the attention training. Effects of the training and of oxytocin on the training will be assessed by means of an eye-tracking anti-saccade task. Based on previous studies showing the strongest effects of threat-attentional bias training in high anxious subjects, the study will recruit participants with an elevated trait anxiety.

Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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oxytocin group

oxytocin treatment

Group Type EXPERIMENTAL

Oxytocin

Intervention Type DRUG

intranasal administration of oxytocin (24IU)

placebo group

placebo treatment

Group Type PLACEBO_COMPARATOR

placebo

Intervention Type DRUG

intranasal administration of placebo (24IU)

Interventions

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Oxytocin

intranasal administration of oxytocin (24IU)

Intervention Type DRUG

placebo

intranasal administration of placebo (24IU)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* male participants with elevated trait anxiety (\> 45 scores as assessed with the State and Trait Anxiety Inventory, Spielberger, 1983)
* without past or current psychiatric or neurological disorders