Mindreading in Adults With Autism Spectrum Disorder

NCT ID: NCT04010409

Last Updated: 2023-04-18

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

60 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-01-08

Study Completion Date

2024-12-31

Brief Summary

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This study aims to investigate the ability of reading emotions by the Eyes task in adults with ASD, and examine the gazing pattern and frontal activation during the task. We plan to recruit 50 adults with ASD and 50 typically-developing adults. Eye-tracking and frontal activation (measured by functional near-infrared spectroscopy) will be examined during the Eyes task.

Detailed Description

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Autism spectrum disorder (ASD) is a clinical syndrome characterized by mindreading deficits, or Theory of Mind deficits. The Reading the Mind in the Eyes task (abbreviated as the Eyes task) was developed to assess the mindreading deficits as a hallmark of social deficits of ASD. This study aims to investigate the ability of reading emotions by the Eyes task in adults with ASD, and examine the gazing pattern and frontal activation during the task. We plan to recruit 50 adults with ASD and 50 typically-developing adults. All the participants will complete clinical measures and the Eyes task. Eye-tracking and frontal activation (measured by functional near-infrared spectroscopy) will be examined during the Eyes task.

Conditions

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Autism Spectrum Disorder

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

CROSS_SECTIONAL

Study Groups

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ASD Group

Autism spectrum disorder participants, no intervention

no intervention

Intervention Type OTHER

no intervention

TD Group

Typically developmental controls,no intervention

no intervention

Intervention Type OTHER

no intervention

Interventions

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no intervention

no intervention

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adult aged between 20 and 50 years who had a diagnosis of ASD based on DSM-5.
* Had a full-scale IQ \> 70 on WAIS-IV.

Exclusion Criteria

* A history of major mental illness (e.g., bipolar affective disorder, schizophrenia) or neurological diseases.
* Visual impairment and that would preclude participation.
Minimum Eligible Age

20 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Taiwan University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Yi Ling Chien, M.D., Ph.D.

Role: PRINCIPAL_INVESTIGATOR

National Taiwan University Hospital

Locations

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National Taiwan University Hospital

Taipei, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Yi Ling Chien, M.D., Ph.D.

Role: CONTACT

886-2-2312-3456 ext. 66013

Facility Contacts

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Yi Ling Chien, M.D., Ph.D.

Role: primary

886-2-2312-3456 ext. 66013

References

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Chien YL, Tseng YL, Tsai WC, Chiu YN. Assessing Frontal Lobe Function on Verbal Fluency and Emotion Recall in Autism Spectrum Disorder by fNIRS. J Autism Dev Disord. 2025 May;55(5):1648-1659. doi: 10.1007/s10803-024-06306-5. Epub 2024 Apr 18.

Reference Type DERIVED
PMID: 38635133 (View on PubMed)

Other Identifiers

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201809069RINA

Identifier Type: -

Identifier Source: org_study_id

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