Clinical Evaluation of a Test for Monitoring the Recurrence of Bladder Cancer

NCT ID: NCT03125460

Last Updated: 2020-02-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

424 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-12-31

Study Completion Date

2019-05-31

Brief Summary

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The objective of this study is to establish the performance characteristics of an assay that detects the recurrence of bladder cancer in patients previously diagnosed with bladder cancer. The study is conducted at locations within and outside of the United States. Testing is performed on urine specimens provided by eligible enrolled patients. Results from this study will not be used for patient management decisions.

Detailed Description

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Conditions

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Bladder Cancer

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Initial Enrollment

Initial enrollment of patients with history of bladder cancer

Xpert Bladder Cancer Monitor

Intervention Type DEVICE

in vitro diagnostic test for the recurrence of bladder cancer in patients that have been previously diagnosed with bladder cancer

Longitudinal Cohort

Longitudinal Cohort - patients considered anticipatory positive at the time of enrollment and one random disease negative patient per anticipatory positive patient

Xpert Bladder Cancer Monitor

Intervention Type DEVICE

in vitro diagnostic test for the recurrence of bladder cancer in patients that have been previously diagnosed with bladder cancer

Interventions

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Xpert Bladder Cancer Monitor

in vitro diagnostic test for the recurrence of bladder cancer in patients that have been previously diagnosed with bladder cancer

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Subject is ≥ 40 years of age
* Subject has provided documented informed consent as required by the reviewing IRB or EC. Experimental Bill of Rights will be documented for all subjects enrolled in applicable states.
* Subject is considered disease positive within 12 months (365 days) of enrollment.
* At the time of the enrollment visit, the subject is scheduled for a standard of care cystoscopy which will be completed within 3 days of providing a urine specimen.
* Subject has agreed to provide at least 60 mL of voided urine for study purposes at the enrollment visit.
* Subject has agreed to provide at least 60 mL of voided urine for study purposes at each subsequent standard of care cystoscopy visit for at least 12 months (365 days) following enrollment if the subject will enter the Longitudinal cohort.
* Any subject considered anticipatory positive at the initial visit shall be enrolled into the longitudinal cohort. For each anticipatory positive enrolled into the longitudinal cohort a random disease negative subject shall be enrolled.

Exclusion

* Subject has been previously enrolled into the study.
* Urine specimen to be used for study purposes is from the first morning void.
* Subject has had an excision procedure within six weeks (42 days) of enrollment.
* The subject is not scheduled for a standard of care cystoscopy visit within 12 months (365 days) following enrollment.
Minimum Eligible Age

40 Years

Maximum Eligible Age

100 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Cepheid

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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PAVA

Palo Alto, California, United States

Site Status

The Urology Center of Colorado, P.C.

Denver, Colorado, United States

Site Status

Urology Associates, P.C.

Englewood, Colorado, United States

Site Status

North Idaho Urology

Coeur d'Alene, Idaho, United States

Site Status

Idaho Urologic Institute

Meridian, Idaho, United States

Site Status

UroPartners

Melrose Park, Illinois, United States

Site Status

Five Valleys Urology

Missoula, Montana, United States

Site Status

Weill Cornell Medicine

New York, New York, United States

Site Status

Stephenson Cancer Center

Oklahoma City, Oklahoma, United States

Site Status

UT Southwestern

Dallas, Texas, United States

Site Status

Virginia Urology

Richmond, Virginia, United States

Site Status

The Male/Female Health and Research Centre

Barrie, Ontario, Canada

Site Status

G Kenneth Jansz Medicine Professional Corp.

Burlington, Ontario, Canada

Site Status

Urology Associates / Urologic Medical Research

Kitchener, Ontario, Canada

Site Status

Urology Clinic of Dr. Goldfarb

North Bay, Ontario, Canada

Site Status

Urologic Clinic of Stanley Flax

North York, Ontario, Canada

Site Status

Radboud University Medical Center

Nijmegen, , Netherlands

Site Status

Countries

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United States Canada Netherlands

Other Identifiers

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170

Identifier Type: -

Identifier Source: org_study_id

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