The Efficacy of the Bladder EpiCheck for Detection of Recurrent Urothelial Cell Carcinoma

NCT ID: NCT02700464

Last Updated: 2021-05-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

680 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-09-30

Study Completion Date

2020-07-31

Brief Summary

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Clinical trial to determine the efficacy (sensitivity and specificity) of the Bladder EpiCheck test compared to the gold standard cystoscopy and pathology in patients under monitoring for recurrence of bladder cancer.

Detailed Description

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The Bladder EpiCheck test is an in vitro diagnostic device for the detection of DNA methylation patterns in urine that are associated with bladder cancer. It is intended for use as a noninvasive method for monitoring for tumor recurrence in conjunction with cystoscopy inpatients previously diagnosed with bladder cancer This is a, multicenter, prospective, blinded study to evaluate the efficacy (sensitivity and specificity) of a novel methylation test for the detection of recurrent Urothelial Cell Carcinoma in patients with a history of bladder cancer undergoing surveillance.

Conditions

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Bladder Cancer

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Bladder EpiCheck Urine Test

Bladder EpiCheck Urine Test

Group Type EXPERIMENTAL

Bladder EpiCheck Urine Test

Intervention Type DEVICE

The Bladder EpiCheck test is an in vitro diagnostic device for the detection of DNA methylation patterns in urine that are associated with bladder cancer. It is intended for use as a noninvasive method for monitoring for tumor recurrence in conjunction with cystoscopy inpatients previously diagnosed with bladder cancer

Gold Standard

Cystoscopy and pathology

Group Type ACTIVE_COMPARATOR

Cystoscopy and pathology

Intervention Type PROCEDURE

Routine cystoscopy for bladder cancer recurrence and pathology confirmation for patients with positive cystoscopy

Interventions

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Bladder EpiCheck Urine Test

The Bladder EpiCheck test is an in vitro diagnostic device for the detection of DNA methylation patterns in urine that are associated with bladder cancer. It is intended for use as a noninvasive method for monitoring for tumor recurrence in conjunction with cystoscopy inpatients previously diagnosed with bladder cancer

Intervention Type DEVICE

Cystoscopy and pathology

Routine cystoscopy for bladder cancer recurrence and pathology confirmation for patients with positive cystoscopy

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Any male or female patient diagnosed with incident or recurrent Urothelial Cell Carcinoma and undergoing surveillance at 3 month intervals.
* Has had all urothelial cell carcinoma tumor resected within the past 12 months
* Has a plan for cystoscopic surveillance (adjuvant intravesical therapy allowed)
* Able to provide legally effective informed consent
* Able to produce 45mL of urine

Exclusion Criteria

* Planning to undergo radical cystectomy or chemotherapy-radiation for Urothelial Cell Carcinoma
Minimum Eligible Age

22 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nucleix Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Shmulik Adler, MSc

Role: STUDY_DIRECTOR

Nucleix Ltd.

Locations

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The Urology Center of Colorado

Denver, Colorado, United States

Site Status

Chesapeake Urology Research Associates

Baltimore, Maryland, United States

Site Status

Michigan Institute of Urology, P.C.

Troy, Michigan, United States

Site Status

Metro Urology

Woodbury, Minnesota, United States

Site Status

Urological Surgeons of Long Island

Garden City, New York, United States

Site Status

Duke University Health System

Durham, North Carolina, United States

Site Status

Cleveland Clinic

Cleveland, Ohio, United States

Site Status

Vanderbilt University Medical Center

Nashville, Tennessee, United States

Site Status

Urology San Antonio

San Antonio, Texas, United States

Site Status

University Of Washington

Seattle, Washington, United States

Site Status

UHN, Princess Margret Cancer center

Toronto, Ontario, Canada

Site Status

Countries

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United States Canada

Other Identifiers

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UC-EpiCheck-FDA-01

Identifier Type: -

Identifier Source: org_study_id

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