Patient-reported Outcomes in Bladder Cancer

NCT ID: NCT03584659

Last Updated: 2022-10-25

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

230 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-01-21

Study Completion Date

2022-03-31

Brief Summary

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Electronic reporting of patient-reported outcomes with alert algorithm will be tested in a randomized trial in bladder cancer patients undergoing chemo- or immunotherapy. The clinical endpoints will be:

* Quality of life
* Completion of treatment
* Hospital admission
* Dose reductions
* Survival

Detailed Description

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Bladder cancer is in Europe the 4th most incident cancer among men and the 7th most frequent cause of cancer death. Many patients will receive chemo- or immunotherapy in either the neoadjuvant setting or for recurrent or metastatic disease. The registration and handling of side effect is crucial in bladder cancer treatment, since the missing identification and insufficient treatment of such can lead to incomplete treatment and thereby decreased effect. It is therefore of utmost importance to develop new tools which can increase identification of the side effects and improve treatment to secure the best life expectancies for these patients.

This study will in a randomized trial using PRO-CTCAE™ questions, EORTC QLQ-C30 + QLQ-BLM30 in one arm versus standard procedure regarding side effect registration and handling in the other arm, test the effect of electronic reporting of side-effects and quality of life with a specifically developed alert-algorithm. Both study arms will include chemotherapy and immunotherapy patients as standard therapy.

Conditions

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Bladder Cancer Urothelial Carcinoma

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Standard of care

This arm will continue standard procedure regarding side effect registration and handling

Group Type NO_INTERVENTION

No interventions assigned to this group

PRO

This arm will be assigned to intervention by weekly electronic reporting of side effects and quality of life. A specifically developed alert-algorithm will in real-time guide both patient and alert clinical staff if symptoms are increasing or quality of life is deteriorating.

Group Type EXPERIMENTAL

Electronic patient-reported outcomes

Intervention Type DEVICE

Weekly reporting of patient-reported outcomes for closer contact between patient and clinic between treatment cycles.

Interventions

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Electronic patient-reported outcomes

Weekly reporting of patient-reported outcomes for closer contact between patient and clinic between treatment cycles.

Intervention Type DEVICE

Other Intervention Names

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Alert-algorithm Real-time guidance of patients when symptom reporting Alerts to clinical staff

Eligibility Criteria

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Inclusion Criteria

* Urothelial carcinoma
* Initiating chemo- or immunotherapy
* No serious cognitive deficits
* Read and understand Danish
* Assigned electronic communication with health services with "E-boks"

Exclusion Criteria

* None
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Herlev Hospital

OTHER

Sponsor Role collaborator

Danish Cancer Society

OTHER

Sponsor Role collaborator

Aalborg University Hospital

OTHER

Sponsor Role collaborator

Odense University Hospital

OTHER

Sponsor Role collaborator

Rigshospitalet, Denmark

OTHER

Sponsor Role lead

Responsible Party

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Helle Pappot

Clinical Oncologist, Consultant, DMSc

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Gry Assam Taarnhøj, MD

Role: PRINCIPAL_INVESTIGATOR

Department of Oncology, Copenhagen University Hospital, Rigshospitalet, Denmark

Locations

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Aalborg University Hospital

Aalborg, , Denmark

Site Status

Department of Oncology, Rigshospitalet

Copenhagen, , Denmark

Site Status

Department of Oncology

Herlev, , Denmark

Site Status

Odense University Hospital

Odense, , Denmark

Site Status

Countries

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Denmark

References

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Taarnhoj GA, Johansen C, Carus A, Dahlrot RH, Dohn LH, Hjollund NH, Knudsen MB, Tolver A, Lindberg H, Pappot H. The iBLAD study: patient-reported outcomes in bladder cancer during oncological treatment: a multicenter national randomized controlled trial. J Patient Rep Outcomes. 2023 Oct 9;7(1):99. doi: 10.1186/s41687-023-00640-5.

Reference Type DERIVED
PMID: 37812306 (View on PubMed)

Other Identifiers

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iBLAD2018

Identifier Type: -

Identifier Source: org_study_id

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