Comparison of Two Apical Repair Methods in Women Undergoing Repairs for Prolapse

NCT ID: NCT03113513

Last Updated: 2024-01-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

NA

Total Enrollment

312 participants

Study Classification

INTERVENTIONAL

Study Start Date

2016-05-01

Study Completion Date

2025-04-30

Brief Summary

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To date no study has determined prospectively which technique is superior to prevent recurrent Pelvic Organ Prolapse (POP) after vaginal hysterectomy- a major unmet clinical need. The aim of the study is to determine objective anatomical recurrent prolapse after Sacrospinous Ligament Fixation (SLF) vs McCall.

Detailed Description

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The aim of the study is to determine objective anatomical recurrent prolapse after SLF vs McCall. The study is designed as a Randomized Controlled Trial (RCT). Primary study endpoint will be at 12 months, secondary study endpoint at 24 months. The following parameters will be evaluated after one year: anatomical outcome, Quality of Life (QoL), sexual health, reoperations, and complications.

Conditions

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Pelvic Organ Prolapse Surgery Quality of Life Complication

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

The study is designed as a RCT.
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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McCall culdoplasty

The McCall culdoplasty will be performed in a modified version as described by McCall in 1957. Specifically, two long acting bioresorbable sutures are put through the specific anatomic landmarks.

Group Type ACTIVE_COMPARATOR

fixation of the vaginal apex

Intervention Type PROCEDURE

In the course of vaginal hysterectomy the vaginal cuff is either fixed to the sacrospinous ligament or to the uterosacral ligament.

Sacrospinous ligament fixation

The SLF technique will be performed as described by Richter et al (Amreich, 1951). Two long acting bioresorbable sutures are passed through the right sacrospinous ligament and then fixed to the vaginal cuff.

Group Type ACTIVE_COMPARATOR

fixation of the vaginal apex

Intervention Type PROCEDURE

In the course of vaginal hysterectomy the vaginal cuff is either fixed to the sacrospinous ligament or to the uterosacral ligament.

Interventions

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fixation of the vaginal apex

In the course of vaginal hysterectomy the vaginal cuff is either fixed to the sacrospinous ligament or to the uterosacral ligament.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* declined/ failed conservative treatment for POP
* planned vaginal hysterectomy with anterior/posterior colporrhaphy as indicated
* any symptomatic POP or stage II prolapse in any compartment
* at least stage I prolapse in the apical department
* women between 35 and 80 years of age
* good German language skills
* any concomitant prolapse surgery (anterior, posterior vaginal repair, suburethral tapes) as indicated
* concomitant salpingo-oophorectomy if indicated

Exclusion Criteria

* Unwillingness to participate
* Neurological disorders
* Previous hysterectomy
* Desire to have children
* Connective tissue disorders (i.e. Ehlers-Danlos syndrome, Marfan syndrome)
Minimum Eligible Age

35 Years

Maximum Eligible Age

80 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Medical University of Graz

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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MUGRAZ

Graz, Styria, Austria

Site Status

Countries

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Austria

References

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Colombo M, Milani R. Sacrospinous ligament fixation and modified McCall culdoplasty during vaginal hysterectomy for advanced uterovaginal prolapse. Am J Obstet Gynecol. 1998 Jul;179(1):13-20. doi: 10.1016/s0002-9378(98)70245-5.

Reference Type BACKGROUND
PMID: 9704759 (View on PubMed)

Other Identifiers

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V4 31.01.2016

Identifier Type: -

Identifier Source: org_study_id

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