Prophylactic Laparoscopic Suspension After McCall

NCT ID: NCT04560543

Last Updated: 2024-11-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

182 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-05-15

Study Completion Date

2029-12-31

Brief Summary

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There is prove of prolapse prevention in vaginal hysterectomy using the McCall suture. Poor and especially no long-term data exists for a standardized laparoscopic approach, but the few studies could show good anatomic results.

The aim is to test the effectiveness of the laparoscopic McCall suture compared to usual vaginal cuff closure in a randomized controlled double-blinded trial.

Detailed Description

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182 patients will be enrolled in the study. We randomize the patient before surgery and information about the procedure will be transmitted to the theatre in a sealed envelope. The surgeon will open the envelope just before surgery. For randomization we apply a 1:1 allocation (standard vaginal cuff closure VS standard vaginal cuff closure with McCall sutures). The McCall suture is standardized: we apply a purse-string suture including both USL and the peritoneum.

Follow-up visits measuring POP-Q are planned after 6 weeks and yearly until 5 years.

Conditions

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Prolapse Pelvic

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Participants Outcome Assessors

Study Groups

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McCall suture

Uterus removal by laparoscopy with usual vaginal closure and additional (McCall) suture, which is intended to prevent descent.

Group Type EXPERIMENTAL

McCall suture

Intervention Type PROCEDURE

Laparoscopic suture including the uterosacral ligaments and the peritoneum

standard cuff closure

Uterus removal by laparoscopy with usual vaginal closure without additional (McCall) suture. (as performed so far)

Group Type SHAM_COMPARATOR

Standard cuff closure

Intervention Type PROCEDURE

Standard laparoscopic barbed suture of the vaginal cuff

Interventions

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McCall suture

Laparoscopic suture including the uterosacral ligaments and the peritoneum

Intervention Type PROCEDURE

Standard cuff closure

Standard laparoscopic barbed suture of the vaginal cuff

Intervention Type PROCEDURE

Other Intervention Names

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Uterosacral Ligament Suspension

Eligibility Criteria

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Inclusion Criteria

* LSC simple hysterectomy,
* Neg. SS test if premenopausal
* \>18j,
* Consent to participate in the study
* Understanding of the German language

Exclusion Criteria

* Prolapse as indication for surgery
* Known or suspected non-compliance
* Additional incontinence procedures
* Patients with deep infiltrating endometriosis
* Irradiation pre- or postoperative
* Pregnancy and lactation.
* Transgender population
* Conversion from laparoscopy to laparotomy
* Inability to understand the study protocol
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Insel Gruppe AG, University Hospital Bern

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Michel D Mueller, Prof.

Role: STUDY_DIRECTOR

Department of Gynaecology, University Hospital, Berne

Locations

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Universitätsfrauenklink Inselspital

Bern, , Switzerland

Site Status RECRUITING

Countries

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Switzerland

Central Contacts

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Diana Höhn, MD

Role: CONTACT

0316321010 ext. 0316321010

Other Identifiers

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2020-01046

Identifier Type: -

Identifier Source: org_study_id

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