Complications Associated With Promontofixation for Pelvic Organ Prolapse: Comparing Robot Assisted Laparoscopic and Non-robot Assisted Laparoscopic Surgical Procedures

NCT ID: NCT01320215

Last Updated: 2025-12-04

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

365 participants

Study Classification

INTERVENTIONAL

Study Start Date

2011-06-22

Study Completion Date

2022-01-25

Brief Summary

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The primary objective of this study is to compare 30-day complication rates associated with promontofixation for pelvic organ prolapse performed via a robot-assisted laparoscopic technique versus a non-robot-assisted laparoscopic technique. Secondary objectives include comparing technical data, anatomical correction, prolapse recurrence, incontinence, quality of life and medico-economic data between the two techniques.

The patient diary did not allow the collection of sufficiently precise data to meet the secondary medico-economic objective of the study. Access to data from the National Health Data System (SDNS), which was not available at the time of the initial drafting of this protocol, now makes it possible to obtain a complete picture of patients' health care consumption. We propose, therefore, to extract data from the SNIIRAM via the SNDS (matching of patients' NIR to their health care consumption) in order to retrieve and accurately estimate the cost of follow-up.

Detailed Description

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Conditions

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Pelvic Organ Prolapse

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Participants

Study Groups

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Robot arm

The patients in this arm will have a robot-assisted promontofixation.

Group Type EXPERIMENTAL

Robot-assisted promontofixation

Intervention Type PROCEDURE

Sacrohysteropexy with robotic assistance (da Vinci robot)

Non-robot arm

The patients in this arm with have a promotofixation via a laparoscopy, but without robot assistance.

Group Type ACTIVE_COMPARATOR

Non-robot assisted promontofixation

Intervention Type PROCEDURE

Laparoscopic sacrohysteropexy, without robot assistance

Interventions

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Robot-assisted promontofixation

Sacrohysteropexy with robotic assistance (da Vinci robot)

Intervention Type PROCEDURE

Non-robot assisted promontofixation

Laparoscopic sacrohysteropexy, without robot assistance

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patient has a first,(primo-event), symptomatic, genito-urinary prolapse of at least stage II (POP-Q classification) requiring surgery
* The patient must have given her informed and signed consent
* The patient must be insured or beneficiary of a health insurance plan
* The patient is available for 60 months of follow-up

Exclusion Criteria

* The patient is participating in another study
* The patient is under judicial protection, under tutorship or curatorship
* The patient refuses to sign the consent
* It is impossible to correctly inform the patient
* The patient is pregnant
* Patient has a stage-1 prolapse (POP-Q classification)
* Patient has asymptomatic prolapse
* The patient has a prolapse recurrence (i.e. this is not the first case of prolapse)
* The patient is not available for 60 months of follow-up
* Patient has a vaginal or urinary infection
* Patient has poorly-adjusted diabetes
* Patient on long-term corticotherapy
* Patient has previously had pelvic radiotherapy
* Patient has contraindication for anesthesia
* Patient has an intestinal inflammatory disease
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Centre Hospitalier Universitaire de Nīmes

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Stéphane Droupy, MD PhD

Role: PRINCIPAL_INVESTIGATOR

Centre Hospitalier Universitaire de Nîmes

Locations

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CHU de Nîmes - Hôpital Universitaire Carémeau

Nîmes, Gard, France

Site Status

Groupe Urologie Saint Augustin

Bordeaux, , France

Site Status

APHP - Centre Hospitalier Henri Mondor

Créteil, , France

Site Status

CHU de Dijon

Dijon, , France

Site Status

CHU de Montpellier - Hôpital Lapeyronie

Montpellier, , France

Site Status

CHU de Nancy - Hôpitaux de Brabois

Nancy, , France

Site Status

CHU de Nantes

Nantes, , France

Site Status

CHU de Nice - Hôpitaux L'Archet 1 et 2

Nice, , France

Site Status

Clinique Kennedy

Nîmes, , France

Site Status

Groupe Hospitalier Diaconesses Croix Saint-Simon - Site Reuilly

Paris, , France

Site Status

APHP - Groupe Hospitalier Pitié-Salpetrière

Paris, , France

Site Status

CHU de Lyon - Centre Hospitalier Lyon Sud

Pierre-Bénite, , France

Site Status

CHU de Rennes - Hôpital PontChaillou

Rennes, , France

Site Status

Clinique Belledonne

Saint Martin d'Héres, , France

Site Status

CHRU de Strasbourg - Hôpital Civil

Strasbourg, , France

Site Status

Hôpital Foch

Suresnes, , France

Site Status

CHRU de Toulouse - Hôpital de Rangueil

Toulouse, , France

Site Status

CHRU de Tours - Hôpital Bretonneau

Tours, , France

Site Status

Countries

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France

References

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Gris JC, Chea M, Bouvier S, Pereira FR. Antiphospholipid Antibodies in Mental Disorders. Semin Thromb Hemost. 2025 Jun;51(4):448-456. doi: 10.1055/s-0044-1788696. Epub 2024 Jul 24.

Reference Type RESULT
PMID: 39047993 (View on PubMed)

Other Identifiers

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2010-A01110-39

Identifier Type: OTHER

Identifier Source: secondary_id

PHRC-N/2010/SD-01

Identifier Type: -

Identifier Source: org_study_id

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