Randomized,Multicentric Study to Treat Prolapse After Hysterectomy With Amreich Procedure or Total Prolift Procedure

NCT ID: NCT00572702

Last Updated: 2009-08-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

200 participants

Study Classification

INTERVENTIONAL

Study Start Date

2007-01-31

Study Completion Date

2009-12-31

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

Head to Head comparison of perioperative complications and secondary the impact of operation techniques with or without mesh on patients suffering from pelvic organ prolapse on quality of life.

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

During the last decade a substantial progress in the detailed knowledge of morphology and function of different compartments of the female pelvic floor was achieved. The obtained informations were quickly implemented in the clinical practice especially in the application of special meshes and of novel techniques of their implantation. Their success rate was evaluated only in pilot companies supported studies. We do miss randomised studies not sponsored by company comparing different surgical techniques and their impact on the quality of life (QoL); the objective estimation of those consequences is for the longlasting effect of the surgery inevitable. The new methods bring also new complications which were not yet relevantly and objectively documented.

In the study we compare the techniques contemporary used - in the groups with or without mesh, in size relevant for the statistical evaluation

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Pelvic Organ Prolapse

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

A

Patients with 3 compartment pelvic organ prolapse after hysterectomy, treated with Amreich-Richter procedure; it will be set randomly

Group Type ACTIVE_COMPARATOR

Vaginal fixation Amreich-Richter

Intervention Type PROCEDURE

Descending vaginal cuff will be treated with fixation of the cuff on sacrospinous ligament

B

Patients with 3 compartment pelvic organ prolapse after hysterectomy, treated with total Prolift procedure; it will be set randomly

Group Type ACTIVE_COMPARATOR

Prolift total

Intervention Type PROCEDURE

Descending vaginal cuff will be treated with insertion of site-specific mesh into the vesico-vaginal and recto-vaginal space

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Vaginal fixation Amreich-Richter

Descending vaginal cuff will be treated with fixation of the cuff on sacrospinous ligament

Intervention Type PROCEDURE

Prolift total

Descending vaginal cuff will be treated with insertion of site-specific mesh into the vesico-vaginal and recto-vaginal space

Intervention Type PROCEDURE

Other Intervention Names

Discover alternative or legacy names that may be used to describe the listed interventions across different sources.

Prolift total - polypropylen mesh

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* female sex
* age 18 and more
* subscribed informed consent
* objective symptoms of prolapse-POP-Q 3 and more according to ICS standards
* compliance of the patient

Exclusion Criteria

* patients with evidence of malignant lesion in small pelvis
* history of radiotherapy in small pelvis
* patients suffering from any form of PID within inclusion process
* pregnancy
* lactation
* total eversion of uterus and vagina
* serious internal disorders
* history of recto- or vesico-vaginal fistula
* history of rejection of any artificial material
* symptoms of primary genuine stress urinary incontinence
* patients who were not able to subscribe the informed consent
* patients, who couldn´t be reached for further follow-up
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

Meet the organizations funding or collaborating on the study and learn about their roles.

Ministry of Health, Czech Republic

OTHER_GOV

Sponsor Role collaborator

Charles University, Czech Republic

OTHER

Sponsor Role lead

Responsible Party

Identify the individual or organization who holds primary responsibility for the study information submitted to regulators.

Inner Grant Agency, Ministry of Health, Czech republic

Principal Investigators

Learn about the lead researchers overseeing the trial and their institutional affiliations.

Michael Halaska, MD,PhD

Role: PRINCIPAL_INVESTIGATOR

Charles University, Prague, Czech Republic

Locations

Explore where the study is taking place and check the recruitment status at each participating site.

Dpt. Obstetrics and gynecology, General Teaching Hospital

Prague, , Czechia

Site Status RECRUITING

Institute for the care of mother and child

Prague, , Czechia

Site Status RECRUITING

Dpt. of gynecology, Central military hospital

Prague, , Czechia

Site Status RECRUITING

Dpt. Obstetrics and gynecology, Teaching hospital Bulovka

Prague, , Czechia

Site Status RECRUITING

Dpt. of Obstetrics and gynecology, Bata hospital

Zlín, , Czechia

Site Status RECRUITING

Countries

Review the countries where the study has at least one active or historical site.

Czechia

Central Contacts

Reach out to these primary contacts for questions about participation or study logistics.

Michael Krcmar, MD

Role: CONTACT

+420607675842

Kamil Svabik, MD

Role: CONTACT

+420603583456

Facility Contacts

Find local site contact details for specific facilities participating in the trial.

Kamil Svabik, MD.

Role: primary

+420603583456

Ladislav Krofta, MD.,PhD.

Role: primary

+420604480886

Tomas Rittstein, MD.

Role: primary

+420606369793

Michal Krcmar, MD.

Role: primary

+420607675842

Zdenek Adamik, MD., PhD.

Role: primary

+420603241176

Other Identifiers

Review additional registry numbers or institutional identifiers associated with this trial.

NR/9309-3 IGA

Identifier Type: -

Identifier Source: secondary_id

NR/9309-3 IGA

Identifier Type: -

Identifier Source: org_study_id

More Related Trials

Additional clinical trials that may be relevant based on similarity analysis.

SCP vs HUSLS for Pelvic Organ Prolapse Repair
NCT02800512 ACTIVE_NOT_RECRUITING NA