Assessment of Myocardial Ischemic-Reperfusion Injury During Off- and On- Pump CABG

NCT ID: NCT03050489

Last Updated: 2023-01-13

Study Results

Results available

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Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

336 participants

Study Classification

OBSERVATIONAL

Study Start Date

2015-09-15

Study Completion Date

2019-05-31

Brief Summary

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Assessment of myocardial ischemic-reperfusion injury during off- and on- pump CABG.

Detailed Description

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Assessment of myocardial ischemic-reperfusion injury during off- and on- pump CABG is monitored by intraoperative measurement of serum level of myeloperoxidase before sternotomy and after sternal closure.

Conditions

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Ischemic Heart Disease Coronary Artery Disease Ischemic Reperfusion Injury CABG

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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On-Pump CABG

Patients with coronary artery bypass graft (CABG) surgery performed with cardiopulmonary bypass.

On-Pump CABG.

Intervention Type PROCEDURE

Standard On-Pump CABG.

Off-Pump CABG

Patients with coronary artery bypass graft (CABG) surgery performed without cardiopulmonary bypass.

Off-Pump CABG.

Intervention Type PROCEDURE

Standard Off-Pump CABG.

BH-CABG MSC.

Patients with coronary artery bypass graft (CABG) surgery performed on beating heart with mechanical support of circulation.

BH-CABG MSC.

Intervention Type PROCEDURE

Patients with coronary artery bypass graft (CABG) surgery performed on beating heart with mechanical support of circulation

Interventions

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On-Pump CABG.

Standard On-Pump CABG.

Intervention Type PROCEDURE

Off-Pump CABG.

Standard Off-Pump CABG.

Intervention Type PROCEDURE

BH-CABG MSC.

Patients with coronary artery bypass graft (CABG) surgery performed on beating heart with mechanical support of circulation

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* ischemic heart disease

Exclusion Criteria

* valve disease
* diabetes millitus
Minimum Eligible Age

30 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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St. Petersburg State Pavlov Medical University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Alexander S Nemkov, PhD, MD

Role: STUDY_DIRECTOR

PSPbGMU

Locations

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First Pavlov State Medical University of St. Petersburg

Saint Petersburg, , Russia

Site Status

Countries

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Russia

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Other Identifiers

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AMIRI-CABG 03/17-11

Identifier Type: -

Identifier Source: org_study_id

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