Evaluating of Role of Myeloperoxidase in Prediction of Outcomes of Cardiac Surgery Procedures.

NCT ID: NCT03786965

Last Updated: 2021-11-16

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

2000 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-12-20

Study Completion Date

2025-12-20

Brief Summary

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The main objection is to investigate molecular biology of myocardial damage during cardiac surgery procedures.

Detailed Description

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To assess outcomes after cardiac surgery procedures. To investigate serum level of myeloperoxidase, morphology of left atrium appendage, to perform genetic analysis and cell biology.

Conditions

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Cardiac Procedure Complication Ischemic Heart Disease Valve Heart Disease Defect Septal

Keywords

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Ischemic Heart Disease Valve Disease Septal Defect Myeloperoxidase Molecular biology Gene analysis

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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On-pump CABG.

On-pump CABG.

Group Type OTHER

On-pump CABG

Intervention Type OTHER

On-pump CABG

Off-pump CABG.

Off-pump CABG.

Group Type OTHER

Off-pump CABG

Intervention Type OTHER

Off-pump CABG

Pump-assisted CABG.

Pump-assisted CABG.

Group Type OTHER

Pump-assisted CABG

Intervention Type OTHER

Pump-assisted CABG

Heart Valve Procedure without CABG.

Heart Valve Procedure without CABG.

Group Type OTHER

Valve Repair Procedure without CABG.

Intervention Type OTHER

Valve Repair Procedure without CABG (open heart procedure).

Heart Valve Procedure with CABG.

Heart Valve Procedure with CABG.

Group Type OTHER

Valve Repair Procedure with CABG.

Intervention Type OTHER

Valve Repair Procedure with CABG (open heart procedure).

Interventions

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On-pump CABG

On-pump CABG

Intervention Type OTHER

Off-pump CABG

Off-pump CABG

Intervention Type OTHER

Pump-assisted CABG

Pump-assisted CABG

Intervention Type OTHER

Valve Repair Procedure without CABG.

Valve Repair Procedure without CABG (open heart procedure).

Intervention Type OTHER

Valve Repair Procedure with CABG.

Valve Repair Procedure with CABG (open heart procedure).

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* ischemic heart disease with indications for operation
* valve disease with indications for operation
* ischemic heart disease combined with valve disease with indications for operation

Exclusion Criteria

* patient refusal
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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St. Petersburg State Pavlov Medical University

OTHER

Sponsor Role lead

Responsible Party

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Aleksandr Nemkov

PhD

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Alexander Nemkov, PhD

Role: STUDY_DIRECTOR

First Saint-Petersburg Medical University

Locations

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Nikolai Bunenkov

Saint Petersburg, Non-US/Non-Canadian, Russia

Site Status RECRUITING

Countries

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Russia

Central Contacts

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Alexander Nemkov, PhD

Role: CONTACT

Phone: +7-921-795-00-47

Email: [email protected]

Vladimir Komok, PhD

Role: CONTACT

Phone: +7-904-632-19-00

Email: [email protected]

Facility Contacts

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Nikolay Bunenkov

Role: primary

Vladimir V Komok, Ph.D

Role: backup

Other Identifiers

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№22/18-H

Identifier Type: -

Identifier Source: org_study_id