Exploration of Cerebral Pathophysiology During and After CABG Using CPB

NCT ID: NCT02941380

Last Updated: 2016-10-21

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

24 participants

Study Classification

OBSERVATIONAL

Study Start Date

2011-07-31

Study Completion Date

2012-02-29

Brief Summary

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Purpose:

The purpose of this study is to examine cerebral oxidative and inflammatory stress and cerebral hemodynamics during and after coronary artery bypass grafting and correlate with postoperative cognitive function.

Detailed Description

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Postoperative cognitive decline is a well-known and well-described complication following coronary artery bypass grafting. Severity ranges from postoperative delirium to stroke, but the majority of patients with postoperative cognitive decline following coronary artery bypass grafting have decline in recent and remote memory in particular.

The reason for the cognitive decline is still not fully understood though many reasons have been proposed.

Inflammation and oxidative stress may contribute to the postoperative cognitive dysfunction which may also be in combination with a reduced cerebral autoregulation.

Conditions

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Ischemic Heart Disease

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Ischemic heart disease

Patients admitted for coronary artery bypass grafting with the use of cardiopulmonary bypass

No interventions assigned to this group

Eligibility Criteria

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Inclusion Criteria

* Patients with ischemic heart disease admitted for coronary artery bypass grafting with the use of cardiopulmonary bypass

Exclusion Criteria

* Cerebrovascular disease
Minimum Eligible Age

18 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Rigshospitalet, Denmark

OTHER

Sponsor Role lead

Responsible Party

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Claus Behrend Christiansen

M.D.

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Kirsten Møller, MD PhD DMSc

Role: STUDY_DIRECTOR

Rigshospitalet, Denmark

Other Identifiers

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H-4-2011-037

Identifier Type: -

Identifier Source: org_study_id

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