Effect of Remote Ischemic Preconditioning on Cognitive Function After Off-Pump Coronary Artery Bypass Graft
NCT ID: NCT00953368
Last Updated: 2009-08-06
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE1
270 participants
INTERVENTIONAL
2009-10-31
2012-03-31
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
QUADRUPLE
Study Groups
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Remote ischemic preconditioning
Remote ischemic preconditioning will be induced by four 5-min cycles of upper limb ischemia and 5-min reperfusion with a blood-pressure cuff inflated to 200 mmHg and be performed before and after the coronary anastomosis
remote ischemic preconditioning
Remote ischemic preconditioning will be induced by four 5-min cycles of upper limb ischemia and 5-min reperfusion with a blood-pressure cuff inflated to 200 mmHg and be performed before and after the coronary anastomosis
control
sham placement of a blood-pressure cuff around the upper limb without inflation
remote ischemic preconditioning
Remote ischemic preconditioning will be induced by four 5-min cycles of upper limb ischemia and 5-min reperfusion with a blood-pressure cuff inflated to 200 mmHg and be performed before and after the coronary anastomosis
Interventions
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remote ischemic preconditioning
Remote ischemic preconditioning will be induced by four 5-min cycles of upper limb ischemia and 5-min reperfusion with a blood-pressure cuff inflated to 200 mmHg and be performed before and after the coronary anastomosis
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Preoperative use of inotropic drugs or mechanical assistant device
* Ejection fraction less than 30%
* Combined operation using CPB such as valve surgery
* Previous psychiatric and neurologic disorder
* Inability to perform the cognitive function test
40 Years
80 Years
ALL
No
Sponsors
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Asan Medical Center
OTHER
Responsible Party
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Asan Medical Center, Department of Anesthesiology and Pain Medicine
Principal Investigators
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In-Cheol Choi, professor
Role: PRINCIPAL_INVESTIGATOR
Asan Medical Center, Department of Anesthesiology and Pain Medicine
Locations
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Department of Anesthesiology and Pain Medicine, University of Ulsan, College of Medicine, Asan Medical Center
Seoul, Seoul, South Korea
Countries
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Central Contacts
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Facility Contacts
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References
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Van Dijk D, Jansen EW, Hijman R, Nierich AP, Diephuis JC, Moons KG, Lahpor JR, Borst C, Keizer AM, Nathoe HM, Grobbee DE, De Jaegere PP, Kalkman CJ; Octopus Study Group. Cognitive outcome after off-pump and on-pump coronary artery bypass graft surgery: a randomized trial. JAMA. 2002 Mar 20;287(11):1405-12. doi: 10.1001/jama.287.11.1405.
Other Identifiers
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RIPC-3862
Identifier Type: -
Identifier Source: org_study_id
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