Application of Remote Ischemic Preconditioning in Patients Undergoing Open Heart Surgeries
NCT ID: NCT01906918
Last Updated: 2013-11-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
120 participants
INTERVENTIONAL
2013-08-31
2015-08-31
Brief Summary
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Detailed Description
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Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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IRPC, Remote preconditioning
This group will be submitted to ischemic preconditioning
IRPC, Remote preconditioning
The patients will be submitted to 5 minutes of upper limb compression by cuff followed by 5 minutes of reperfusion. This cycle will be repeated 4 times.
Control
This patients will be submitted to the standard surgery protocol in the institution. The patients will not be submitted to 5 minutes of upper limb compression by cuff followed by 5 minutes of reperfusion.
No interventions assigned to this group
Interventions
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IRPC, Remote preconditioning
The patients will be submitted to 5 minutes of upper limb compression by cuff followed by 5 minutes of reperfusion. This cycle will be repeated 4 times.
Eligibility Criteria
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Inclusion Criteria
* Scheduled for coronary artery bypass grafting with or without valve replacement associated
* Use of blood cardioplegia
* EuroSCORE II greater than or equal to 1.0%
Exclusion Criteria
* Complications in the admission
* Pregnant patients
* Severe peripheral arterial disease affecting the upper limbs
* Liver failure (bilirubin ˃ 20 mmol / L, INR 2.0 ˃)
* Significant pulmonary disease (˂ FEV1 40%)
* Renal failure with glomerular filtration rate ˂ ml/min/1,73 m²
* Concomitant treatment with glibenclamide or nicorandil (medications that interfere with cardioprotection induced by IPCR)
18 Years
80 Years
ALL
No
Sponsors
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University of Campinas, Brazil
OTHER
Responsible Party
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Orlando Petrucci
Phd
Principal Investigators
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Orlando Petrucci, MD, PhD
Role: STUDY_CHAIR
University of Campinas
Fany Lima, RN
Role: PRINCIPAL_INVESTIGATOR
University of Campinas
Locations
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Hospital das Clínicas da Unicamp
Campinas, São Paulo, Brazil
Countries
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Central Contacts
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Facility Contacts
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Fany Lima
Role: primary
Other Identifiers
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RIPC
Identifier Type: -
Identifier Source: org_study_id