Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
842 participants
OBSERVATIONAL
2014-11-30
2018-12-31
Brief Summary
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1. Quantify age-related decline in a variety of visual functions within a populations based cohort.
2. Explore the mechanisms underlying age-related visual impairments.
3. Investigate how visual function impacts vision related quality of life.
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Detailed Description
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Group 1: 25 participants from each decade from 20-90. Those from 50+ will be recruited from the NICOLA study and retinal/lens images assessed to confirm normality (drusen \<63µm or clear retina, LOCS III \<1). Those younger will be recruited via advertisements in the University and targeting friends and relatives or NICOLA participants. This will enable the rate of decline with age to be calculated. Linear, bilinear, and simple nonlinear candidate functions of parameter vs. age will be applied to determine which best characterises the change.
Group 2: 250 participants NICOLA participants aged 60 will be invited to participate; only those whose ocular images confirm normality will be included. This will enable mechanisms underlying individual differences in aging to be investigated. Normal aging will be determined from group 1 analysis and participants will be able to be categorised as aging well or aging poorly. Multivariate regression analysis will be used to investigate the relationship between visual function and lifestyle and environmental factors. Principal components analysis will be used to look at the relationships between visual parameters. These participants will also be asked to complete the NEIVFQ-25, to characterise visual function related quality of life and this will be compared with their measured visual function.
Visual function parameters measured after protocol refraction will include: Photopic and mesopic visual acuity and contrast sensitivity using City Occupational acuity-plus software17, near visual acuity, reading speed and SKILL card18, MAIA microperimetry and cone dark adaptation.19 Intra-ocular scatter will be assessed using the Oculus C-quant to assess the extent to which ocular factors are degrading vision.20 Three-point vernier acuity will also be measured as this is thought to stay stable throughout life.15 Time will be taken to ensure participants receive sufficient training to produce reliable thresholds.
All study visits will occur at the Welcome-Wolfson Clinic Research Facility.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Study Groups
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Group 1 - aged 20-90 years
25 participants from each decade from 20-90. Those from 50+ will be recruited from the NICOLA study and retinal/lens images assessed to confirm normality.
No interventions assigned to this group
Group 2: aged 60 years
Group 2: 250 participants NICOLA participants aged 60 will be invited to participate; only those whose ocular images confirm normality will be included.
No interventions assigned to this group
Eligibility Criteria
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Inclusion Criteria
* Non-diabetic.
Exclusion Criteria
* Diabetic.
* Cognitive impairment.
20 Years
90 Years
ALL
Yes
Sponsors
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College of Optometrists
UNKNOWN
Queen's University, Belfast
OTHER
Responsible Party
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Ruth Hogg
Doctor
Principal Investigators
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Ruth Hogg
Role: PRINCIPAL_INVESTIGATOR
Queen's University, Belfast
Locations
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NI Clinical Research Facility
Belfast, Northern Ireland, United Kingdom
Countries
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Other Identifiers
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14.25
Identifier Type: -
Identifier Source: org_study_id
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