Visual Mode Switching in Color Perception

NCT ID: NCT05779228

Last Updated: 2026-01-14

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2026-01-01

Study Completion Date

2032-02-04

Brief Summary

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Participants will be given experience wearing colored lenses that add a tint to the environment. Changes in visual perception and neural processing that arise as a result of this experience will be measured. These are expected as participants learn to switch to "colored lenses mode" where the effects of the lenses are discounted and colors appear more normal as soon as the lenses are put on.

Detailed Description

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All participants will wear tinted lenses for 1 hour at a time, 5 times per day. Perception (behavior) and neural function (with functional MRI and EEG) before and after this experience will be measured. In the neural measurements, activity will be recorded while participants view stripes of many different colors both with the lenses on and off. In the perceptual measurements, participants will adjust the color of a small patch to appear neutral, neither red nor green. Behavior will be measured in a variety of conditions to test different hypotheses about the origins of the mode-switching effects. These include: 1) surrounding the patch with different colors, 2) preceding the presentation of the patch with presentation of different colors, 3) presenting the tests in a red-illuminated room, 4) presenting the tests in a completely darkened room, and 5) using a head-mount-display (virtual reality goggles) to present simulated lenses that gradually change in strength.

Conditions

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Perception of Things Changing Color Adaptive Behavior

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

The interventional study type is correct. The investigative team is giving all subjects a treatment- behavioral training in visual mode switching- and measuring effects of that treatment, by comparing measures made before to measures made after the treatment. Thus, this is a within-subjects, repeated measures experimental design. The experimenters have 6 different measurements they are using this design in different groups of subjects run in parallel, all examining different effects of the same treatment. . This is why parallel study model is appropriate. These parallel groups with different measurements, but same treatment, are the arms of the study.
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Color Contrast

Test patch is surrounded spatially by different colors

Group Type EXPERIMENTAL

Mode Switching Training

Intervention Type BEHAVIORAL

Wear of colored lenses for 1 hr, 5 times per day, for 5 days

Color Adaptation

Test patch is surrounded temporally (preceded) by different colors

Group Type EXPERIMENTAL

Mode Switching Training

Intervention Type BEHAVIORAL

Wear of colored lenses for 1 hr, 5 times per day, for 5 days

Neuroimaging

Functional MRI and Electroencephelography data are acquired for multiple test colors

Group Type EXPERIMENTAL

Mode Switching Training

Intervention Type BEHAVIORAL

Wear of colored lenses for 1 hr, 5 times per day, for 5 days

Red Room

Participants are tested in a red-illuminated room

Group Type EXPERIMENTAL

Mode Switching Training

Intervention Type BEHAVIORAL

Wear of colored lenses for 1 hr, 5 times per day, for 5 days

Dark Room

Participants are tested in a completely darkened room

Group Type EXPERIMENTAL

Mode Switching Training

Intervention Type BEHAVIORAL

Wear of colored lenses for 1 hr, 5 times per day, for 5 days

Gradual Change

Participants view a gradual change in tint, presented on a head-mounted display

Group Type EXPERIMENTAL

Mode Switching Training

Intervention Type BEHAVIORAL

Wear of colored lenses for 1 hr, 5 times per day, for 5 days

Interventions

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Mode Switching Training

Wear of colored lenses for 1 hr, 5 times per day, for 5 days

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Normal or corrected to normal vision by contact lenses
* No known visual disorders
* Little to no experience in tinted environments (e.g. dark rooms, swimming goggles)

Exclusion Criteria

* Abnormal color vision
Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Minnesota

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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University of Minnesota

Minneapolis, Minnesota, United States

Site Status

Countries

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United States

References

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Li Y, Tregillus KE, Luo Q, Engel SA. Visual mode switching learned through repeated adaptation to color. Elife. 2020 Dec 15;9:e61179. doi: 10.7554/eLife.61179.

Reference Type RESULT
PMID: 33320093 (View on PubMed)

Other Identifiers

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STUDY00002354

Identifier Type: -

Identifier Source: org_study_id

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