BCI and Evaluation of Visual and Task Performance in Subjects With Eye Diseases

NCT ID: NCT03318549

Last Updated: 2024-11-26

Study Results

Results available

Outcome measurements, participant flow, baseline characteristics, and adverse events have been published for this study.

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Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

115 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-10-29

Study Completion Date

2023-05-31

Brief Summary

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The purpose of this research study is to better understand the impact of visual impairment caused by different eye diseases on the ability to perform daily activities and compare it to that in patients without eye diseases.

Detailed Description

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Conditions

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Glaucoma Macular Degeneration Glaucoma Suspect Optic Neuropathy Retinal Degeneration Visual Pathway Disorder

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Glaucoma group

Patients with diagnosed glaucoma will be in the group for up to 5 years.

Group Type OTHER

Visual Performance tests

Intervention Type DIAGNOSTIC_TEST

Participants came to the clinic in person for 2 hours for visual performance tests once every 6 months for up to 5 years. These tests included virtual reality tests and tests on a computer screen to investigate performance during simulated daily life activities, such as driving, situations of low contrast and glare.

Brain-computer interface

Intervention Type DEVICE

The brain-computer interface (BCI) consists of a modified virtual reality goggle integrated with wireless no-prep electroencephalogram (EEG). The portable BCI is able to objectively measure multifocal steadystate visual evoked potentials in response to brain stimulation through presentation of visual stimuli in the goggle. The test is done in person and may take up to 30 minutes, once every 6 months for up to 5 years.

Suspicious of having glaucoma group

Patients with suspicious of having glaucoma will be in the group for up to 5 years.

Group Type OTHER

Visual Performance tests

Intervention Type DIAGNOSTIC_TEST

Participants came to the clinic in person for 2 hours for visual performance tests once every 6 months for up to 5 years. These tests included virtual reality tests and tests on a computer screen to investigate performance during simulated daily life activities, such as driving, situations of low contrast and glare.

Brain-computer interface

Intervention Type DEVICE

The brain-computer interface (BCI) consists of a modified virtual reality goggle integrated with wireless no-prep electroencephalogram (EEG). The portable BCI is able to objectively measure multifocal steadystate visual evoked potentials in response to brain stimulation through presentation of visual stimuli in the goggle. The test is done in person and may take up to 30 minutes, once every 6 months for up to 5 years.

Non-glaucomatous optic neuropathies group

Patients with optic neuropathies that do not look glaucomatous-like will be in the group for up to 5 years.

Group Type OTHER

Visual Performance tests

Intervention Type DIAGNOSTIC_TEST

Participants came to the clinic in person for 2 hours for visual performance tests once every 6 months for up to 5 years. These tests included virtual reality tests and tests on a computer screen to investigate performance during simulated daily life activities, such as driving, situations of low contrast and glare.

Age-related macular degeneration (AMD) group

Patients with diagnosed age-related macular degeneration will be in the group for up to 5 years.

Group Type OTHER

Visual Performance tests

Intervention Type DIAGNOSTIC_TEST

Participants came to the clinic in person for 2 hours for visual performance tests once every 6 months for up to 5 years. These tests included virtual reality tests and tests on a computer screen to investigate performance during simulated daily life activities, such as driving, situations of low contrast and glare.

Retinal degenerations group

Patients with other retinal degenerations excluding AMD will be in the group for up to 5 years.

Group Type OTHER

Visual Performance tests

Intervention Type DIAGNOSTIC_TEST

Participants came to the clinic in person for 2 hours for visual performance tests once every 6 months for up to 5 years. These tests included virtual reality tests and tests on a computer screen to investigate performance during simulated daily life activities, such as driving, situations of low contrast and glare.

Other diseases of visual pathways group

Other diseases of the visual pathway not included in the previous groups will be in the group for up to 5 years.

Group Type OTHER

Visual Performance tests

Intervention Type DIAGNOSTIC_TEST

Participants came to the clinic in person for 2 hours for visual performance tests once every 6 months for up to 5 years. These tests included virtual reality tests and tests on a computer screen to investigate performance during simulated daily life activities, such as driving, situations of low contrast and glare.

Healthy control group

Patients labeled as healthy controls for not having any other eye diseases that would be included on the other groups will be in the group for up to 5 years.

Group Type OTHER

Visual Performance tests

Intervention Type DIAGNOSTIC_TEST

Participants came to the clinic in person for 2 hours for visual performance tests once every 6 months for up to 5 years. These tests included virtual reality tests and tests on a computer screen to investigate performance during simulated daily life activities, such as driving, situations of low contrast and glare.

Brain-computer interface

Intervention Type DEVICE

The brain-computer interface (BCI) consists of a modified virtual reality goggle integrated with wireless no-prep electroencephalogram (EEG). The portable BCI is able to objectively measure multifocal steadystate visual evoked potentials in response to brain stimulation through presentation of visual stimuli in the goggle. The test is done in person and may take up to 30 minutes, once every 6 months for up to 5 years.

Interventions

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Visual Performance tests

Participants came to the clinic in person for 2 hours for visual performance tests once every 6 months for up to 5 years. These tests included virtual reality tests and tests on a computer screen to investigate performance during simulated daily life activities, such as driving, situations of low contrast and glare.

Intervention Type DIAGNOSTIC_TEST

Brain-computer interface

The brain-computer interface (BCI) consists of a modified virtual reality goggle integrated with wireless no-prep electroencephalogram (EEG). The portable BCI is able to objectively measure multifocal steadystate visual evoked potentials in response to brain stimulation through presentation of visual stimuli in the goggle. The test is done in person and may take up to 30 minutes, once every 6 months for up to 5 years.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Subjects must be between the ages of 18 and 90 years old;
* Both males and females will be included.
* Be able and willing to provide signed informed consent and follow study instructions

Exclusion Criteria

* Subjects will be excluded if they present with any systemic conditions that in the opinion of the Principal Investigator may prevent them from completing the tests.
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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National Eye Institute (NEI)

NIH

Sponsor Role collaborator

University of Miami

OTHER

Sponsor Role lead

Responsible Party

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Felipe Andrade Medeiros

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Felipe A Medeiros, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Miami

Henry Tseng, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Duke University

Locations

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Bascom Palmer Eye Institute

Miami, Florida, United States

Site Status

Countries

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United States

Provided Documents

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Document Type: Study Protocol and Statistical Analysis Plan

View Document

Document Type: Informed Consent Form

View Document

Other Identifiers

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Pro00088016

Identifier Type: OTHER

Identifier Source: secondary_id

R01EY029885

Identifier Type: NIH

Identifier Source: secondary_id

View Link

20240020

Identifier Type: -

Identifier Source: org_study_id

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