Visual Motor Coordination

NCT ID: NCT00568243

Last Updated: 2024-04-12

Basic Information

• Recruitment Status: TERMINATED
• Total Enrollment: 34 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2007-12-04
• Study Completion Date: 2024-04-09

Brief Summary

Background:

• The relation between eye movement and brain function is a subject of interest to the National Eye Institute.
• By comparing eye movement in healthy volunteers to research conducted on patients who have difficulty moving their eyes, the National Eye Institute hopes to develop and improve diagnostic procedures for people with eye diseases.

Objectives:

-The purpose of this study is to understand how we see visual patterns and how we move our eyes to see.

Eligibility:

• Normal volunteers:

• must have no serious illnesses and must be 18 years of age or older
• are able to follow directions and pay attention to visual stimuli and respond as appropriate
• individuals with a history of eye or brain diseases, or previous eye or eye muscle surgery, are not allowed to participate in this study. Individuals who are currently using eye medications also are not eligible for the study.
• Patients:

• who are 18 years of age or older
• are able to follow directions and pay attention to visual stimuli and respond as appropriate

Design:

• Participants will visit the National Eye Institute outpatient clinic for examination and testing.
• Participants will be screened with a medical history and eye examination (including eye pressure and eye movement tests).
• Participants with healthy eyes will participate in eye movement testing experiments:

• One or more sessions lasting less than three hours each.
• Eye movements will be recorded with a video/infrared camera system.
• For the majority of the studies done under this protocol, only one or two sessions will be required. A few studies recording very small eye movements will require three or more sessions.

Detailed Description

Study Description: This natural history study will investigate eye movements and other responses to visual stimuli in normal individuals (normal volunteers) and patients. Normal adult volunteers will be recruited and will undergo an eye exam to assure that there are no visual system problems. . Volunteers will be studied in one or more sessions where eye movement, verbal, or hand movement responses are recorded in response to visual stimuli. Patients with diseases affecting the oculomotor or visual systems will also be recruited to help us better understand these systems and to help characterize their specific disease.

Objectives:

The objective is to study normal volunteers and patients for eye movement and other responses to visual stimuli with the goal of better understanding human vision and neural control of eye movements.

Endpoints:

The primary outcome measure is eye movement and other responses to visual stimuli.

Conditions

Healthy Volunteer; Neurodegenerative Diseases

Study Design

• Observational Model Type: CASE_ONLY
• Study Time Perspective: PROSPECTIVE

Study Groups

Normal Volunteer

Healthy subjects without neurodegenerative diseases

No interventions assigned to this group

Patients

Subjects with neurodegenerative diseases

No interventions assigned to this group

Eligibility Criteria

Inclusion Criteria

In order to be eligible to participate in this study, an individual must meet all of the following criteria:

1. Participant must be a volunteer with no ocular, visual, or oculomotor problems.

2. Participant must be 18 years old or older.

3. Participant must be able to follow directions and actively pay attention to visual stimuli and respond as appropriate.

4. For studies which use the contact lens, participant must be able to tolerate a contact lens in either one or both eyes.

In order to be eligible to participate in this study, an individual must meet all of the following criteria

1. Participant must be 18 years old or older.

2. Participant must be able to follow directions and actively pay attention to visual stimuli and respond as appropriate.

3. For studies which use the contact lens, participant must be able to tolerate a contact lens in either one or both eyes.

Exclusion Criteria

An individual who meets any of the following criteria will be excluded from participation in this

study:

An individual who meets any of the following criteria will be excluded from participation in thisstudy:

1. Participant has a history of ocular or visual diseases or diseases affecting the nervous system (including myasthenia, MS, etc.) or any diseases which might affect control of eye movements or affect vision.

2. Participant has had prior eye or eye muscle surgery.

3. Participant has a history of eye patching (amblyopia or lazy eye).

4. Participant currently uses eye drops or ocular medications.

An individual who meets any of the following criteria will be excluded from participation in this study:

1. Patient is unable to cooperate with testing, including sitting still while eye movements are recorded.

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 120 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

National Eye Institute (NEI)

NIH

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Rich J Krauzlis, Ph.D.

Role: PRINCIPAL_INVESTIGATOR

National Eye Institute (NEI)

Locations

National Institutes of Health Clinical Center

Bethesda, Maryland, United States

Countries

United States

Related Links

https://clinicalstudies.info.nih.gov/cgi/detail.cgi?A_2008-EI-0031.html

NIH Clinical Center Detailed Web Page

Other Identifiers

08-EI-0031

Identifier Type: -

Identifier Source: secondary_id

080031

Identifier Type: -

Identifier Source: org_study_id