The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery
NCT ID: NCT02756715
Last Updated: 2020-02-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
80 participants
INTERVENTIONAL
2016-05-30
2020-02-27
Brief Summary
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The purpose of this study is to prove the variation of level of serum syndecan-1 between preoperative and postoperative period.
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Detailed Description
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1. Preoperation (immediate before anesthesia induction)
2. Immediate before tourniquet off
3. 5 min after tourniquet off
4. PACU
5. postoperative 6 hours
6. postoperative 24 hours
Serum in blood will be obtained and level of serum cytokine will be evaluated by enzyme-linked immunosorbent assay
Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
SINGLE
Study Groups
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propofol group
The patient who anesthetized by using propofol.
propofol group
Patient will be anesthetized by using propofol infusion during operation.
Desflurane group
The patient who anesthetized by using sevoflurane.
Desflurane group
Patient will be anesthetized by using desflurane inhalation during operation.
Interventions
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propofol group
Patient will be anesthetized by using propofol infusion during operation.
Desflurane group
Patient will be anesthetized by using desflurane inhalation during operation.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* history of previous cancer
* history of previous peripheral vascular disease
* Emergency surgery
20 Years
ALL
No
Sponsors
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Konkuk University Medical Center
OTHER
Responsible Party
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Seong-Hyop Kim
Associate Professor
Principal Investigators
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Seong-Hyop Kim, M.D,Ph.D
Role: PRINCIPAL_INVESTIGATOR
Konkuk University Medical Center
Locations
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Konkuk University Medical Center
Seoul, , South Korea
Countries
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References
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Oh CS, Choi JM, Park EH, Piao L, Park HJ, Rhee KY, Kim SH. Impact of Anesthetic Agents on Endothelial Glycocalyx Injury during Total Knee Arthroplasty: Desflurane- vs. Propofol-Based Anesthesia-A Prospective Randomized Controlled Trial. Biomed Res Int. 2021 Jan 23;2021:8880267. doi: 10.1155/2021/8880267. eCollection 2021.
Other Identifiers
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KUH1160100
Identifier Type: -
Identifier Source: org_study_id
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