Peripheral Metabolic Function in Chronic Heart Failure Patients

NCT ID: NCT02732990

Last Updated: 2016-04-11

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 60 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2014-02-28
• Study Completion Date: 2016-08-31

Brief Summary

Exercise intolerance is a major limiting symptom in patients with CHF. However the poor correlation between the hemodynamic parameters of left ventricular performance at rest and exercise performance has led to the concept that peripheral factors such as muscle perfusion and muscle metabolism play a role as determinants of exercise capacity.

Detailed Description

The pathophysiology behind the breathlessness and fatigue experienced by CHF patients during exercise remains unclear. Recent evidence suggests that the peripheral skeletal muscle, which becomes abnormal in heart failure, is the source of afferent signals which disrupt normal patterns of cardiorespiratory control. When CHF patients exercise, an inappropriately strong sympathetic response further limits exercise tolerance by evoking larger than normal increases in peripheral sympathetic activation at a faster rate than in healthy individuals. A consequence of this exacerbated sympathetic response may be the further sympathetic restraint of blood flow to the active skeletal muscles resulting in hypoperfusion of the muscle vascular bed and fatigue. Small muscle mass exercise training increases muscle oxidative capacity and improves aerobic work capacity in CHF patients. A range of studies is proposed here that will provide an integrative view of the mechanistic basis behind exercise intolerance in CHF and relate the intramuscular metabolic status to the autonomic control of hemodynamics during exercise. An understanding of the mechanistic basis of the improved exercise tolerance with training, independent of improved resting cardiac function, will yield important information regarding the integrated control of blood flow and metabolic demand in CHF and highlight the importance of maintaining the integrity of the peripheral musculature in CHF.

Conditions

Chronic Heart Failure

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: HEALTH_SERVICES_RESEARCH
• Blinding Strategy: SINGLE

Study Groups

Exercise training - Whole body exercise

Control subjects will train 2-legged cycling (whole body exercise) for 6 weeks

Group Type: EXPERIMENTAL

Exercise training

Intervention Type: BEHAVIORAL

All gruoups will undergo 6 weeks of training intervention either with a small musclemass (one-legged exercise) or whole body exercise (two-legged cycling)

Exercise training - One-legged exercise

Control subjects will train high intense one-legged exercise for 6 weeks

Group Type: EXPERIMENTAL

Exercise training

Intervention Type: BEHAVIORAL

All gruoups will undergo 6 weeks of training intervention either with a small musclemass (one-legged exercise) or whole body exercise (two-legged cycling)

Exercise training - 2-legged cycling CHF

CHF patients will train 2-legged cycling (whole body exercise) for 6 weeks

Group Type: EXPERIMENTAL

Exercise training

Intervention Type: BEHAVIORAL

All gruoups will undergo 6 weeks of training intervention either with a small musclemass (one-legged exercise) or whole body exercise (two-legged cycling)

Exercise training - CHF

CHF Patients will train high intense one-legged exercise for 6 weeks

Group Type: EXPERIMENTAL

Exercise training

Intervention Type: BEHAVIORAL

All gruoups will undergo 6 weeks of training intervention either with a small musclemass (one-legged exercise) or whole body exercise (two-legged cycling)

Interventions

Exercise training

All gruoups will undergo 6 weeks of training intervention either with a small musclemass (one-legged exercise) or whole body exercise (two-legged cycling)

Intervention Type: BEHAVIORAL

Eligibility Criteria

Inclusion Criteria

• New York Heart Association (NYHA) Class II - III
• Ejection fraction <35%
• Heart failure as a result of previous myocardial infarction
• Optimal treatment (ACE-inhibitors, beta-blockers)
• Stable heart failure
• Patients with and without implantable cardioverter defibrillator (ICD)

Exclusion Criteria

• Peripheral vascular disease with symptoms of atherosclerosis (intermittent claudication)
• Aneurysm in a. femoral
• Moderate to severe heart valve disease
• Moderate to severe Chronic Obstructive Pulmonary Disease (COPD) with FEV1 <60%
• Heart Failure Patients with Biventricular pacemaker (BVP)
• Serious heart rhythm disturbances (arrhythmias such as atrial fibrillation and frequent premature ventricular contractions)
• Myocardial infarction within the last month
• Unstable angina (angina pectoris)
• Renal failure (creatinine greater than 2.5 mg / dL)
• Severe systemic disease of the nervous system, pulmonary or other severe organ involvement
• BMI> 30
• Pregnancy

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 70 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Anders Rasmussen Rinnov

OTHER

Sponsor Role: lead

Responsible Party

Anders Rasmussen Rinnov

CIM administrator

Responsibility Role: SPONSOR_INVESTIGATOR

Principal Investigators

Stefan P Mortensen, Dr. Med

Role: STUDY_CHAIR

IMM - Department of Cardiovascular and Renal Research

Locations

Centre of Inflammation and Metabolism (CIM), Centre for Physical Activity Research

Copenhagen, , Denmark

Site Status: RECRUITING

Countries

Denmark

Central Contacts

Gregers W Munch, MSc PhD

Role: CONTACT

gregers.munch@regionh.dk

+45 35459574

Facility Contacts

Gregers W Munch, MSc PhD

Role: primary

gregers.munch@regionh.dk

+45 35459574

Other Identifiers

VEK-H-3-2013-048

Identifier Type: -

Identifier Source: org_study_id