Eccentric Resistance Training Among Individuals With Chronic Heart Failure

NCT ID: NCT06032780

Last Updated: 2025-11-19

Basic Information

• Recruitment Status: RECRUITING
• Clinical Phase: NA
• Total Enrollment: 84 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2023-09-20
• Study Completion Date: 2026-05-31

Brief Summary

To determine the effects of eccentric resistive training on ventricle functions and aerobic capacity as compared to a resistance and aerobic training among Heart failure (HF)

Conditions

Heart Failure

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: OTHER
• Blinding Strategy: DOUBLE

Study Groups

Eccentric Resistive Training + Aerobic training Group

Group Type: EXPERIMENTAL

Eccentric Resistive Training + Aerobic training Group

Intervention Type: OTHER

Eccentric Resistive training includes upper limb (biceps and triceps) and lower limb large muscle training (quadriceps and hamstrings) 2 sets of 12 repetitions (reps) for each group of muscles in lengthened position for eccentric training in approx. 20 minutes (min). Intensity will be based on 1 repetition maximum (1RM) starting from 20% of (1RM) and its intensity in percentage will be progress by 10% after every two weeks. Stair descending training and squatting position and eccentric hamstring curls with weights at ankle for lower limb eccentric training progressive as per tolerance in response to modified Borg scale (with cut off of showing dyspnea of 4 somewhat hard) and Numeric Pain rating scale (with cut off of showing 7 on scale, crossing moderate pain) . (approx. 20 min).

+ Aerobic training as a control will be given to this group as well for approximately 30 minutes per session.

Resistance Training + Aerobic training Group

Group Type: ACTIVE_COMPARATOR

Resistance Training + Aerobic training Group

Intervention Type: OTHER

Resistive training (concentric) includes Upper limb (biceps and triceps) and lower limb large muscle training (quadriceps and hamstrings), 2 sets of 12 reps for each group of muscles in approx. 30 min. Intensity will be based on 1 repetition maximum (1RM) starting from 20% of (1RM) and its intensity in percentage will be progress by 10% after every two weeks. Stair climbing training and quadriceps training + standing hamstring curls with weight at ankle for lower limb concentric training progressive as per tolerance in response to modified Borg scale (with cut off of showing dyspnea of 4 somewhat hard) and Numeric Pain rating scale (with cut off of showing 7 on scale, crossing moderate pain)

+ Aerobic training as a control will be given to this group as well for approximately 30 minutes per session.

Aerobic training Group

Group Type: ACTIVE_COMPARATOR

Aerobic training Group

Intervention Type: OTHER

Aerobic training as a control will be given to this group as well for approximately 60 minutes per session. Aerobic training exercise will be completed via a ergometer/stationary cycle; type will be continuous aerobic exercise and intensity of 60% of max HR (or peak VO2) in HF individuals.

Interventions

Eccentric Resistive Training + Aerobic training Group

Eccentric Resistive training includes upper limb (biceps and triceps) and lower limb large muscle training (quadriceps and hamstrings) 2 sets of 12 repetitions (reps) for each group of muscles in lengthened position for eccentric training in approx. 20 minutes (min). Intensity will be based on 1 repetition maximum (1RM) starting from 20% of (1RM) and its intensity in percentage will be progress by 10% after every two weeks. Stair descending training and squatting position and eccentric hamstring curls with weights at ankle for lower limb eccentric training progressive as per tolerance in response to modified Borg scale (with cut off of showing dyspnea of 4 somewhat hard) and Numeric Pain rating scale (with cut off of showing 7 on scale, crossing moderate pain) . (approx. 20 min).

+ Aerobic training as a control will be given to this group as well for approximately 30 minutes per session.

Intervention Type: OTHER

Resistance Training + Aerobic training Group

Resistive training (concentric) includes Upper limb (biceps and triceps) and lower limb large muscle training (quadriceps and hamstrings), 2 sets of 12 reps for each group of muscles in approx. 30 min. Intensity will be based on 1 repetition maximum (1RM) starting from 20% of (1RM) and its intensity in percentage will be progress by 10% after every two weeks. Stair climbing training and quadriceps training + standing hamstring curls with weight at ankle for lower limb concentric training progressive as per tolerance in response to modified Borg scale (with cut off of showing dyspnea of 4 somewhat hard) and Numeric Pain rating scale (with cut off of showing 7 on scale, crossing moderate pain)

+ Aerobic training as a control will be given to this group as well for approximately 30 minutes per session.

Intervention Type: OTHER

Aerobic training Group

Aerobic training as a control will be given to this group as well for approximately 60 minutes per session. Aerobic training exercise will be completed via a ergometer/stationary cycle; type will be continuous aerobic exercise and intensity of 60% of max HR (or peak VO2) in HF individuals.

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Diagnosis of Chronic HF and currently stable with optimal medical therapy
• Chronic Heart failure with ejection fraction > 30 %
• Patient able to safely perform lower limb exercise will be check by six- minute walk test (6 MWT)

Exclusion Criteria

• Those Heart failure patient whose are in acute phase or planed for any immediate medical intervention
• Already participating in cardiac rehabilitation
• New York Heart Association (NYHA) Classification of HF class IV HF symptoms
• Co-existent other disease such as asthma/ COPD/interstitial lung disease.
• Symptomatic Second degree or third degree heart block.
• ECG with uncontrolled ventricular arrhythmia
• Limited Exercise ability due to neurologic or orthopedic impairments of the legs (will cross-check with 6 MWT)

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Riphah International University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Muhammad Iqbal Tariq, PhD*

Role: PRINCIPAL_INVESTIGATOR

Riphah International University

Arshad Nawaz Malik, PhD

Role: STUDY_CHAIR

Riphah International University

Shane Patman, PhD

Role: STUDY_CHAIR

University of Notre Dame Australia

Locations

Pakistan Railway Hospital

Rawalpindi, Punjab Province, Pakistan

Site Status: SUSPENDED

Rawalpindi Institute of Cardiology

Rawalpindi, Punjab Province, Pakistan

Site Status: RECRUITING

Countries

Pakistan

Central Contacts

Muhammad Iqbal Tariq, PhD*

Role: CONTACT

iqbal.tariq@riphah.edu.pk

+923338236752

Facility Contacts

Muhammad Iqbal Tariq, PhD*

Role: primary

iqbal.tariq@riphah.edu.pk

+92 333 8236752

Other Identifiers

ISB/REC/PhD/01199 Iqbal Tariq

Identifier Type: -

Identifier Source: org_study_id