Combined Effect of Aerobic and Resistance Exercise in Non Ischemic Dilated Cardiomyopathy Patients

NCT ID: NCT07062874

Last Updated: 2025-07-14

Basic Information

• Recruitment Status: NOT_YET_RECRUITING
• Clinical Phase: NA
• Total Enrollment: 66 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2025-07-28
• Study Completion Date: 2025-10-10

Brief Summary

This study explores the effects of combined aerobic and resistance exercise in patients with non-ischemic dilated cardiomyopathy (NIDCM). In a six-week randomized clinical trial with 66 participants, both exercise groups-combined and aerobic-only-showed significant improvements in exercise capacity, functional independence, dyspnea, and blood pressure. However, no significant difference was found between the two groups. The study concludes that both exercise approaches are effective, but longer studies are needed to determine if combined training offers added benefits.

Detailed Description

The study titled "Combined Effect of Aerobic and Resistance Exercise in Non-Ischemic Dilated Cardiomyopathy Patients" by Arooj Fatima investigates how integrating both aerobic and resistance exercises impacts patients suffering from NIDCM, a condition marked by left ventricular dysfunction and reduced exercise tolerance. Through a randomized clinical trial involving 66 patients divided into two groups-one receiving both aerobic and resistance training and the other only aerobic training-the study evaluated changes in ejection fraction, VO₂ max, dyspnea, and functional independence over six weeks. Significant improvements were observed within both groups across all measured outcomes, including increased exercise capacity, better functional independence, and reduced blood pressure and dyspnea levels. However, no statistically significant difference was found between the two groups, indicating that while both exercise regimens are beneficial, the combined approach did not yield superior results within the study's timeframe. The research highlights the value of structured exercise in improving cardiovascular and functional outcomes in NIDCM patients and recommends longer, more varied studies to further explore these benefits.

Conditions

CARDIOMYOPATHY

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: PARALLEL
• Primary Study Purpose: TREATMENT
• Blinding Strategy: SINGLE

Study Groups

Combined Aerobic and Resistance Exercise:

Participants performed aerobic training three times a week for six weeks.

Each session included a 10-minute warm-up, 30-minute main aerobic activity (60-85% of heart rate reserve using the Karvonen formula), and 10-minute cool-down.

Additionally, they performed resistance exercises for upper and lower extremities using TheraBands, 8-10 sets covering major muscle groups, three times a week.

Group Type: EXPERIMENTAL

Combined Aerobic and Resistance Exercise

Intervention Type: BEHAVIORAL

Participants received supervised exercise training 3 times per week for 6 weeks. Each session included a 10-minute warm-up (walking at 1.5 km/h), a 30-minute aerobic phase at 60-85% heart rate reserve (calculated using the Karvonen formula), and a 10-minute cool-down (walking at 1 km/h). In addition, participants performed resistance training for upper and lower extremities using TheraBands, with 8-10 sets targeting major muscle groups.

Aerobic Exercise Only

Intervention Type: BEHAVIORAL

Participants followed the same aerobic training protocol as the experimental group-3 sessions per week for 6 weeks, with 10-minute warm-up, 30-minute aerobic exercise (60-85% HRR), and 10-minute cool-down. No resistance training was provided.

Aerobic Exercise Only

Participants followed the same aerobic training protocol as Group A.

No resistance training was included.

Sessions also occurred three times a week for six weeks, with similar warm-up, active, and cool-down phases.

Group Type: ACTIVE_COMPARATOR

Aerobic Exercise Only

Intervention Type: BEHAVIORAL

Participants followed the same aerobic training protocol as the experimental group-3 sessions per week for 6 weeks, with 10-minute warm-up, 30-minute aerobic exercise (60-85% HRR), and 10-minute cool-down. No resistance training was provided.

Interventions

Combined Aerobic and Resistance Exercise

Participants received supervised exercise training 3 times per week for 6 weeks. Each session included a 10-minute warm-up (walking at 1.5 km/h), a 30-minute aerobic phase at 60-85% heart rate reserve (calculated using the Karvonen formula), and a 10-minute cool-down (walking at 1 km/h). In addition, participants performed resistance training for upper and lower extremities using TheraBands, with 8-10 sets targeting major muscle groups.

Intervention Type: BEHAVIORAL

Aerobic Exercise Only

Participants followed the same aerobic training protocol as the experimental group-3 sessions per week for 6 weeks, with 10-minute warm-up, 30-minute aerobic exercise (60-85% HRR), and 10-minute cool-down. No resistance training was provided.

Intervention Type: BEHAVIORAL

Other Intervention Names

Resistance training

Eligibility Criteria

Inclusion Criteria

• Both male and female Age 40 to 60
• Left ventricular ejection fraction <50%

Exclusion Criteria

• Patients diagnosed with valvular heart disease, supraventricular arrhythmias, congenital heart disease were excluded.
• Neuromuscular diseases such as stroke, Parkinson.
• Underlying pulmonary disease
• Impaired cognitive function (14)

• Minimum Eligible Age: 40 Years
• Maximum Eligible Age: 60 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Riphah International University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Arjumand Bano, MS-CPPT

Role: PRINCIPAL_INVESTIGATOR

Riphah International University

Locations

Arjumand

Lahore, Punjab Province, Pakistan

Countries

Pakistan

Central Contacts

imran amjad, phd

Role: CONTACT

imran.amjad@riphah.edu.pk

03324390125

Facility Contacts

Arjumand Bano, MS-CPPT

Role: primary

arjumand.bano@riphah.edu.pk

03059551883

Other Identifiers

REC/RCR&AHS/24/0359

Identifier Type: -

Identifier Source: org_study_id